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CYP2C8 gene polymorphism and bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma

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CYP2C8 gene polymorphism and bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma

dc.contributor.author	Such Taboada, Esperanza	es_ES
dc.contributor.author	Cervera, José	es_ES
dc.contributor.author	Terpos, Evangelos	es_ES
dc.contributor.author	Bagán Sebastián, José Vicente	es_ES
dc.contributor.author	Avaria, Amparo	es_ES
dc.contributor.author	Gómez Seguí, Inés	es_ES
dc.contributor.author	Margaix Muñoz, María	es_ES
dc.contributor.author	Ibañez, Mariam	es_ES
dc.contributor.author	Luna del Valle, Irene	es_ES
dc.contributor.author	Cordón Gallego, Lourdes	es_ES
dc.contributor.author	Roig, Mónica	es_ES
dc.contributor.author	Sanz Alonso, Miguel Ángel	es_ES
dc.contributor.author	Dimopoulos, Meletios A.	es_ES
dc.contributor.author	Rubia, Javier de la	es_ES
dc.date.accessioned	2015-06-22T09:52:42Z
dc.date.available	2015-06-22T09:52:42Z
dc.date.issued	2011	es_ES
dc.identifier.citation	Haematologica Vol. 96 Issue 10: pp. 1557-1559	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44688
dc.description.abstract	Osteonecrosis of the jaw is an uncommon but potentially serious complication of bisphosphonate therapy in multiple myeloma. Previous studies showed that the presence of one or two minor alleles of the cytochrome P450, subfamily 2C polypeptide 8 gene (CYP2C8) polymorphism rs1934951 was an independent prognostic marker associated with development of osteonecrosis of the jaw in multiple myeloma patients treated with bisphosphonates. The aim of this study was to validate the frequency of SNP rs193451 in 79 patients with multiple myeloma. In 9 (22%) patients developing osteonecrosis of the jaw, a heterozygous genotype was found, in contrast with those who did not develop osteonecrosis of the jaw (n=4, 11%) or healthy individuals (n=6, 13%). We found no differences in the cumulative risk of developing osteonecrosis of the jaw between patients homozygous and heterozygous for the major allele. We were unable to confirm a significant association between this polymorphism and the risk of developing osteonecrosis of the jaw.	es_ES
dc.subject	CYP2C8	es_ES
dc.subject	ONJ	es_ES
dc.subject	bisphosphonates	es_ES
dc.subject	multiple myeloma	es_ES
dc.title	CYP2C8 gene polymorphism and bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.3324/haematol.2011.042572	es_ES
dc.identifier.idgrec	077972	es_ES