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Neuroprotective Actions of Estradiol and Novel Estrogen Analogs in Ischemia: Translational Implications

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Neuroprotective Actions of Estradiol and Novel Estrogen Analogs in Ischemia: Translational Implications

dc.contributor.author	Etgen, Anne M.	es_ES
dc.contributor.author	Jover Mengual, Teresa	es_ES
dc.contributor.author	Suzanne Zukin, R.	es_ES
dc.date.accessioned	2015-06-22T09:52:42Z
dc.date.available	2015-06-22T09:52:42Z
dc.date.issued	2010	es_ES
dc.date.issued	2011	es_ES
dc.identifier.citation	Vol. 32 Issue 3: pp. 336-352	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44689
dc.description.abstract	This review highlights our investigations into the neuroprotective efficacy of estradiol and other estrogenic agents in a clinically relevant animal model of transient global ischemia, which causes selective, delayed death of hippocampal CA1 neurons and associated cognitive deficits. We find that estradiol rescues a significant number of CA1 pyramidal neurons that would otherwise die in response to global ischemia, and this is true when hormone is provided as a long-term pretreatment at physiological doses or as an acute treatment at the time of reperfusion. In addition to enhancing neuronal survival, both forms of estradiol treatment induce measurable cognitive benefit in young animals. Moreover, estradiol and estrogen analogs that do not bind classical nuclear estrogen receptors retain their neuroprotective efficacy in middle-aged females deprived of ovarian hormones for a prolonged duration (8 weeks). Thus, non-feminizing estrogens may represent a new therapeutic approach for treating the neuronal damage associated with global ischemia.	es_ES
dc.subject	stroke	es_ES
dc.subject	global ischemia	es_ES
dc.subject	neuroprotection	es_ES
dc.subject	estradiol	es_ES
dc.subject	hippocampus	es_ES
dc.subject	estrogen receptor	es_ES
dc.subject	insulin-like growth factor-1	es_ES
dc.subject	GPR30	es_ES
dc.subject	apoptosis	es_ES
dc.subject	CREB	es_ES
dc.title	Neuroprotective Actions of Estradiol and Novel Estrogen Analogs in Ischemia: Translational Implications	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.1016/j.yfrne.2010.12.005	es_ES
dc.identifier.idgrec	078471	es_ES
dc.identifier.idgrec	072197