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Lipid peroxidation and total antioxidant capacity in vitreous, aqueous humor, and blood samples from patients with diabetic retinopathy

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Lipid peroxidation and total antioxidant capacity in vitreous, aqueous humor, and blood samples from patients with diabetic retinopathy

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dc.contributor.author Mancino, Raffaele es_ES
dc.contributor.author Di Pierro, Donato es_ES
dc.contributor.author Varesi, Chiara es_ES
dc.contributor.author Cerulli, Angelica es_ES
dc.contributor.author Feraco, Alessandra es_ES
dc.contributor.author Cedrone, Claudio es_ES
dc.contributor.author Pinazo Durán, María Dolores es_ES
dc.contributor.author Coletta, Massimiliano es_ES
dc.contributor.author Nucci, Carlo es_ES
dc.date.accessioned 2015-06-22T09:53:29Z
dc.date.available 2015-06-22T09:53:29Z
dc.date.issued 2011 es_ES
dc.identifier.citation Molecular Vision Vol. 17 pp. 1298-1304 es_ES
dc.identifier.uri http://hdl.handle.net/10550/44710
dc.description.abstract PurposeTo evaluate levels of malondialdehyde and the total antioxidant capacity (TAC) in the blood, aqueous humor, and vitreous bodies of diabetic and nondiabetic patients. We also measured the blood energy charge potential (ECP).MethodsWe examined 19 patients with type 2 diabetes mellitus and diabetic retinopathy. Ten were scheduled for cataract surgery and pars plana vitrectomy because of proliferative diabetic retinopathy (PDR). The other nine, with mild nonproliferative PDR (NPDR), and fourteen nondiabetic, age-matched subjects enrolled as a control group were scheduled for cataract surgery and vitrectomy because of epiretinal membranes. Blood, aqueous humor and vitreous body samples were collected at the time of surgery. Malondialdehyde concentrations and blood ECP were measured with high-performance liquid chromatography. The TAC of the samples was estimated with the oxygen radical absorbance capacity method.ResultsThe level of blood and vitreous malondialdehyde in the PDR group was significantly higher compared to controls and to NPDR patients. PDR patients also had lower levels of TAC at the vitreous body and aqueous humor level, but not at the blood level, compared to controls and with NPDR patients. In all diabetic patients, the blood ECP values were significantly lower, compared to control subjects.ConclusionsOur data support the hypothesis that oxidative stress and the decrease of antioxidant defenses are associated with the progression of diabetic retinopathy to its proliferative form. Antioxidant supply may have the effect of correcting oxidative stress and inhibiting disease progression. es_ES
dc.title Lipid peroxidation and total antioxidant capacity in vitreous, aqueous humor, and blood samples from patients with diabetic retinopathy es_ES
dc.type journal article es_ES

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