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Human Endometrial Side Population Cells Exhibit Genotypic, Phenotypic and Functional Features of Somatic Stem Cells

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Human Endometrial Side Population Cells Exhibit Genotypic, Phenotypic and Functional Features of Somatic Stem Cells

dc.contributor.author	Cervelló Alcaraz, Irene	es_ES
dc.contributor.author	Gil-Sanchis, Claudia	es_ES
dc.contributor.author	Mas, Aymara	es_ES
dc.contributor.author	Delgado Rosas, Francisco Manuel	es_ES
dc.contributor.author	Martínez-Conejero, José Antonio	es_ES
dc.contributor.author	Galán, Amparo	es_ES
dc.contributor.author	Martínez-Romero, Alicia	es_ES
dc.contributor.author	Martínez, Sebastián	es_ES
dc.contributor.author	Navarro, Ismael	es_ES
dc.contributor.author	Ferro, Jaime	es_ES
dc.contributor.author	Horcajadas Almansa, José Antonio	es_ES
dc.contributor.author	Esteban, Francisco José	es_ES
dc.contributor.author	O'Connor Blasco, José Enrique	es_ES
dc.contributor.author	Pellicer Martínez, Antonio	es_ES
dc.contributor.author	Simón Vallés, Carlos	es_ES
dc.date.accessioned	2015-06-29T10:32:27Z
dc.date.available	2015-06-29T10:32:27Z
dc.date.issued	2010	es_ES
dc.identifier.citation	PLoS ONE Vol. 5 Issue 6:	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44794
dc.description.abstract	During reproductive life, the human endometrium undergoes around 480 cycles of growth, breakdown and regeneration should pregnancy not be achieved. This outstanding regenerative capacity is the basis for women's cycling and its dysfunction may be involved in the etiology of pathological disorders. Therefore, the human endometrial tissue must rely on a remarkable endometrial somatic stem cells (SSC) population. Here we explore the hypothesis that human endometrial side population (SP) cells correspond to somatic stem cells. We isolated, identified and characterized the SP corresponding to the stromal and epithelial compartments using endometrial SP genes signature, immunophenotyping and characteristic telomerase pattern. We analyzed the clonogenic activity of SP cells under hypoxic conditions and the differentiation capacity in vitro to adipogenic and osteogenic lineages. Finally, we demonstrated the functional capability of endometrial SP to develop human endometrium after subcutaneous injection in NOD-SCID mice. Briefly, SP cells of human endometrium from epithelial and stromal compartments display genotypic, phenotypic and functional features of SSC.	es_ES
dc.title	Human Endometrial Side Population Cells Exhibit Genotypic, Phenotypic and Functional Features of Somatic Stem Cells	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.1371/journal.pone.0010964	es_ES
dc.identifier.idgrec	062093	es_ES