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Deletion of the PER3 Gene on Chromosome 1p36 in Recurrent ER-Positive Breast Cancer

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Deletion of the PER3 Gene on Chromosome 1p36 in Recurrent ER-Positive Breast Cancer

dc.contributor.author	Climent, Joan	es_ES
dc.contributor.author	Perez-Losada, Jesus	es_ES
dc.contributor.author	Quigley, David A.	es_ES
dc.contributor.author	Kim, Il-Jin	es_ES
dc.contributor.author	Delrosario, Reyno	es_ES
dc.contributor.author	Jen, Kuang-Yu	es_ES
dc.contributor.author	Bosch Campos, Ana	es_ES
dc.contributor.author	Lluch Hernández, Ana	es_ES
dc.contributor.author	Mao, Jian-Hua	es_ES
dc.contributor.author	Balmain, Allan	es_ES
dc.date.accessioned	2015-06-29T10:34:08Z
dc.date.available	2015-06-29T10:34:08Z
dc.date.issued	2010	es_ES
dc.identifier.citation	Journal of Clinical Oncology Vol. 28 Issue 23: pp. 3770-3778	es_ES
dc.identifier.uri	http://hdl.handle.net/10550/44800
dc.description.abstract	PurposeTo investigate the role of the PER3 circadian rhythm gene, located within the commonly deleted region of chromosome 1p36, in human breast cancer development.Patients and MethodsThe frequency of genetic alterations at 1p36 and PER3 gene copy number status were analyzed in 180 lymph node–negative breast cancers from patients who had received treatment with chemotherapy and/or tamoxifen. The expression levels of PER3 were also analyzed using published microarray profiles from > 400 breast cancer samples. Finally, the effect of loss of Per3 on tumor susceptibility was tested using two mouse models of breast cancer.ResultsDeletion of PER3 is directly related to tumor recurrence in patients with estrogen receptor (ER) – positive breast cancers treated with tamoxifen. Low expression of PER3 mRNA is associated with poor prognosis, particularly in a subset of tumors that are ER positive, and either luminal A or ERBB2-positive tumors. Mice deficient in Per3 showed increased susceptibility to breast cancer induced by carcinogen treatment or by overexpression of Erbb2.ConclusionDisruption of PER3 function may serve as an indicator of probability of tumor recurrence in patients with ER-positive tumors. Further investigations of this pathway may reveal links between deregulation of sleep homeostasis and breast tumorigenesis.	es_ES
dc.title	Deletion of the PER3 Gene on Chromosome 1p36 in Recurrent ER-Positive Breast Cancer	es_ES
dc.type	journal article	es_ES
dc.identifier.doi	10.1200/JCO.2009.27.0215	es_ES
dc.identifier.idgrec	063441	es_ES