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Toxicity test of a dental commercial composite

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Toxicity test of a dental commercial composite

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dc.contributor.author Ponce Bravo, Santa es
dc.contributor.author Ledesma Montes, Constantino es
dc.contributor.author Martínez Rivera, José Luis es
dc.contributor.author Garcés Ortíz, Maricela es
dc.date.accessioned 2015-06-29T11:46:25Z
dc.date.available 2015-06-29T11:46:25Z
dc.date.issued 2015 es
dc.identifier.citation Ponce Bravo, Santa ; Ledesma Montes, Constantino ; Martínez Rivera, José Luis ; Garcés Ortíz, Maricela. Toxicity test of a dental commercial composite. En: Journal of Clinical and Experimental Dentistry, 2015, Vol. 7, No. 2: 289-292 es
dc.identifier.uri http://hdl.handle.net/10550/44850
dc.description.abstract Background: International rules must be followed for testing biosecurity in dental materials. A new brand of restorative material appeared in the market and regulations indicated that it should be tested for toxicity. Objectives: The aim of this study was to determine the 90-day sub chronic toxicity of one triethylene glycol dimethacrylate containing composite (MEDENTAL Light-Cure Composite™) orally administered to rats according to Organization for Economic Co-Operation and Development no. 48 guidelines and the requirements specified in the ISO 10993-11. Material and Methods: Wistar rats ate the polymerized composite during 90 days and were observed to determine changes in their behavior, eye and skin signs and other attitudes such as aggressiveness, posture, walking and response to handling. After 90 days were sacrificed to ascertain blood alterations, we did special hematological tests and assessed microscopic slides from 33 different organs. Results: We recorded no significant changes in clinical behavior of the animals. Microscopic review of the H&E stained slides obtained from the analyzed organs showed no abnormal inflammatory or cytological changes and all hematological special tests were within normal limits. Conclusions: Results of this study show that under our experimental conditions the MEDENTAL Light-Cure Composite™ does not produce inflammatory or cytological changes suggestive of toxicity en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Toxicity test of a dental commercial composite es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES

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