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Beneficial effect of shikonin on experimental colitis induced by dextran sulfate sodium in Balb/C mice.

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Beneficial effect of shikonin on experimental colitis induced by dextran sulfate sodium in Balb/C mice.

dc.contributor.author	Andújar Pérez, Isabel
dc.contributor.author	Ríos Cañavate, José Luis
dc.contributor.author	Giner Pons, Rosa María
dc.contributor.author	Cerdá Nicolás, Miguel
dc.contributor.author	Recio Iglesias, María del Carmen
dc.date.accessioned	2015-06-30T10:02:47Z
dc.date.available	2015-06-30T10:02:47Z
dc.date.issued	2012
dc.identifier.citation	Andújar Pérez, Isabel Ríos Cañavate, José Luis Giner Pons, Rosa María Cerdá Nicolás, Miguel Recio Iglesias, María del Carmen 2012 Beneficial effect of shikonin on experimental colitis induced by dextran sulfate sodium in Balb/C mice. Evidence-based Complementary and Alternative Medicina ID 271606 1 15
dc.identifier.uri	http://hdl.handle.net/10550/44863
dc.description.abstract	The naphthoquinone shikonin, a major component of the root of Lithospermum erythrorhizon, now is studied as an antiinflammatory agent in the treatment of ulcerative colitis (UC). Acute UC was induced in Balb/Cmice by oral administration of 5% dextran sodium sulfate (DSS). The disease activity index was evaluated, and a histologic study was carried out. Orally administered shikonin reduces induced UC in a dose-dependent manner, preventing the shortening of the colorectum and decreasing weight loss by 5% while improving the appearance of feces and preventing bloody stools. The disease activity index score was much lower in shikonin-treated mice than in the colitic group, as well as the myeloperoxidase activity. The expression of cyclooxygenase-2 was reduced by 75%, activation of NF-κB was reduced by 44%, and that of pSTAT-3 by 47%, as well as TNF-α, IL-1β, and IL-6 production. Similar results were obtained in primary macrophages culture. This is the first report of shikonin¿s ability to attenuate acute UC induced by DSS. Shikonin acts by blocking the activation of two major targets: NF-κB and STAT-3, and thus constitutes a promising potential therapeutic agent for the management of the inflammatory bowel disease.
dc.language.iso	eng
dc.relation.ispartof	Evidence-based Complementary and Alternative Medicina, 2012, vol. ID 271606, p. 1 -15
dc.subject	Farmacologia
dc.subject	Antiinflamatoris
dc.title	Beneficial effect of shikonin on experimental colitis induced by dextran sulfate sodium in Balb/C mice.
dc.type	journal article	es_ES
dc.date.updated	2015-06-30T10:02:47Z
dc.identifier.doi	10.1155/2012/271606
dc.identifier.idgrec	102979
dc.rights.accessRights	open access	es_ES