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Soft tissue recurrent ameloblastomas also show some malignant features: a clinicopathological study of a 15-year database

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Soft tissue recurrent ameloblastomas also show some malignant features: a clinicopathological study of a 15-year database

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dc.contributor.author Lin, Zitong es
dc.contributor.author Sun, Guowen es
dc.contributor.author Wang, Tiemei es
dc.contributor.author Hu, Qingang es
dc.contributor.author Chen, Fei es
dc.contributor.author Wen, Shanhui es
dc.date.accessioned 2015-07-06T07:21:12Z
dc.date.available 2015-07-06T07:21:12Z
dc.date.issued 2015 es
dc.identifier.citation Lin, Zitong ; Sun, Guowen ; Wang, Tiemei ; Hu, Qingang ; Chen, Fei ; Wen, Shanhui. Soft tissue recurrent ameloblastomas also show some malignant features: a clinicopathological study of a 15-year database. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2015, Vol. 20, No. 3: 12- es
dc.identifier.uri http://hdl.handle.net/10550/45041
dc.description.abstract Background: To investigate the clinicopathological features of six cases of soft tissue recurrent ameloblastoma and explore the role of increased aggressive biological behavior in the recurrences and treatment of this type of ameloblastomas. Material and Methods: In this study, we retrospectively reviewed recurrent ameloblastomas during a 15-year period; six cases were diagnosed as soft tissue recurrent ameloblastoma. The clinical, radiographic, cytological and immunohistochemical records of these six cases were investigated and analyzed. Results: All the six soft tissue recurrent ameloblastomas occurred after radical bone resection, and were located in the adjacent soft tissues around the osteotomy regions. In Case 4, the patient developed pulmonary metastasis, extensive skull-base infiltration and cytological malignancy after multiple recurrences and malignant transformation was diagnosed. In the other five cases, although there were no cytological signs are sufficient to justify an ameloblastoma as malignant, some malignant features were observed. In Case 1, the tumor showed moderate atypical hyperplasia and the Ki-67 staining percentage was 40% positive, which are strongly suggestive of potential malignance. In Case 5, the patient developed a second soft tissue recurrence in the parapharyngeal region and later died of tumor-related complications. All the remaining three patients showed cytology atypia of varying degrees and high expression of PCNA or Ki-67, which confirmed active cell proliferation. Conclusions: Increased aggressiveness is an important factor of soft tissue recurrence. An intraoperative rapid pathological examination and more radical treatment are suggested for these cases. en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Soft tissue recurrent ameloblastomas also show some malignant features: a clinicopathological study of a 15-year database es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES
dc.identifier.url http://dialnet.unirioja.es/servlet/citart?info=link&codigo=5122589&orden=0 es

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