Starting from a recent model of the eta'N interaction, we evaluate the eta'-nucleus optical potential, including the contribution of lowest order in density, t rho/2m(eta'), together with the second-order terms accounting for eta' absorption by two nucleons. We also calculate the formation cross section of the eta' bound states from (pi(+), p) reactions on nuclei. The eta'-nucleus potential suffers from uncertainties tied to the poorly known eta'N interaction, which can be partially constrained by the experimental modulus of the eta'N scattering length and/or the recently measured transparency ratios in eta' nuclear photoproduction. Assuming an attractive interaction and taking the claimed experimental value vertical bar a(eta'N)vertical bar = 0.1 fm, we obtain an eta' optical potential in nuclear matter at saturation density of V eta' = -(8.7 + 1.8i) MeV, not attractive enough to produce eta' bound states in light nuclei. Larger values of the scattering length give rise to deeper optical potentials, with moderate enough imaginary parts. For a value vertical bar a(eta'N)vertical bar = 0.3 fm, which can still be considered to lie within the uncertainties of the experimental constraints, the spectra of light and medium nuclei show clear structures associated to eta'-nuclear bound states and to threshold enhancements in the unbound region.