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Intermittent administration of parathyroid hormone improves the repairing process of rat calvaria defects: a histomorphometric and radiodensitometric study

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Intermittent administration of parathyroid hormone improves the repairing process of rat calvaria defects: a histomorphometric and radiodensitometric study

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dc.contributor.author Silva, Eduardo de Paula es
dc.contributor.author Vasconcelos, Daniel Fernando Pereira es
dc.contributor.author Marques, Marcelo Rocha es
dc.contributor.author Dias da Silva, Marco Antonio es
dc.contributor.author Manzi, Flávio Ricardo es
dc.contributor.author Barros, Silvana Pereira es
dc.date.accessioned 2015-09-21T08:40:58Z
dc.date.available 2015-09-21T08:40:58Z
dc.date.issued 2015 es
dc.identifier.citation Silva, Eduardo de Paula ; Vasconcelos, Daniel Fernando Pereira ; Marques, Marcelo Rocha ; Dias da Silva, Marco Antonio ; Manzi, Flávio Ricardo ; Barros, Silvana Pereira . Intermittent administration of parathyroid hormone improves the repairing process of rat calvaria defects: a histomorphometric and radiodensitometric study. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2015, Vol. 20, No. 4: 14- es
dc.identifier.uri http://hdl.handle.net/10550/47158
dc.description.abstract Background: The aim of this study was to evaluate the effects of intermittent treatment of parathyroid hormone (PTH (1-34)) on the bone regeneration of critically-sized rat calvarial bone defects. Material and Methods: Thirty-two male rats were trephined (4mm fullthickness diameter), in the central part of the parietal bones and divided into 2 groups of 16. The PTH group received subcutaneous injections of PTH (1-34) at 40μg/kg, 3 times a week and the control (CTL) group received the vehicle in the same regimen. The rats were sacrificed at 4 weeks post-treatment regimen, the parietal bones were extracted and samples were evaluated through histomorphometry and radiodensitometry. Results: The histological observations showed that the PTH group presented more “island-like” new bone between the defect margins with fibrous tissues than did the CTL group. The PTH group significantly exhibited greater histologic bone formation than did the CTL group (1.5mm ±0.7; 1.9 mm ± 0.6, p <0.05/ for residual bone defect). The radiodensitometry analysis revealed significant differences among the PTH and CTL groups (2.1 Al eq. ±0.04; 1.8Al eq. ±0.06, p <0.05), demonstrating an increase in bone mineral density. The PTH treatment contributed to the bone formation with a higher amount of mineral and/or fibrous tissue when compared with the CTL group. Conclusions: The results suggest that it was possible to increase the process of bone regeneration by accelerating the healing process in rat calvarial defects through intermittent administration of the PTH treatment. en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Intermittent administration of parathyroid hormone improves the repairing process of rat calvaria defects: a histomorphometric and radiodensitometric study es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES
dc.identifier.url http://dialnet.unirioja.es/servlet/citart?info=link&codigo=5177691&orden=0 es

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