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Toxicity of a dental adhesive compared with ionizing radiation and zoledronic acid

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Toxicity of a dental adhesive compared with ionizing radiation and zoledronic acid

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dc.contributor.author Alcaraz Baños, Miguel es
dc.contributor.author Olivares Rueda, Amparo es
dc.contributor.author Achel, Daniel Giyngiri es
dc.contributor.author García Cruz, Emilio es
dc.contributor.author Fondevilla Soler, Adriana es
dc.contributor.author Canteras Jordana, Manuel es
dc.date.accessioned 2015-09-21T08:41:00Z
dc.date.available 2015-09-21T08:41:00Z
dc.date.issued 2015 es
dc.identifier.citation Alcaraz Baños, Miguel ; Olivares Rueda, Amparo ; Achel, Daniel Giyngiri ; García Cruz, Emilio ; Fondevilla Soler, Adriana ; Canteras Jordana, Manuel. Toxicity of a dental adhesive compared with ionizing radiation and zoledronic acid. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2015, Vol. 20, No. 4: 7- es
dc.identifier.uri http://hdl.handle.net/10550/47168
dc.description.abstract Background: To determine the toxicity of aqueous dilutions of a universal self-priming dental adhesive (DA) and comparing these with those elicited by exposure to ionizing radiation (IR), Zoledronic acid (Z) treatment and the synergic effects of the combined treatment with IR+Z. Material and Methods: The genotoxic effect of DA was determined by the increase in the frequency of micronuclei in cytokinesis-blocked in cultured human lymphocytes before and after exposure to 2Gy of X-rays. The cytotoxic effect was studied by using the MTT cell viability test in normal prostate cell lines (PNT2) after exposure to different X-ray doses (0Gy-20Gy). The cell lines divided into different groups and treated with different test substances: DA in presence of O 2 , DA in absence of O 2 , Z-treated and control. Results: An in vitro dose-dependent and time-dependent cytotoxic effect of DA, Z and IR on PNT2 cells ( p >0.001) was demonstrated. DA without-O 2 , following the recommendations of manufacturers, had a more pronounced effect of increasing cell death than DA with-O 2 ( p <0.001). In the genotoxicity assay, DA at 25% of its original concentration significantly increased chromosome damage ( p <0.001). The samples studied were found to be toxic, and the samples photo-polymerized in absence of O 2 showed a bigger cytotoxic effect comparable to the additive toxic effect showed by the combined treatment of IR+Z. Conclusions: Additional effort should be carried out to develop adhesives, which would reduce the release of hazardus substances; since toxic effects are similar to that reported by other agents whose clinical use is controlled by the health authorities. en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Toxicity of a dental adhesive compared with ionizing radiation and zoledronic acid es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES
dc.identifier.url http://dialnet.unirioja.es/servlet/citart?info=link&codigo=5177681&orden=0 es

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