Background: Dentin surface contaminated with haemostatic agents can interfere with the bonding of self-adhesive resin cement. Therefore the purpose of this study was to evaluate the effect of various haemostatic agents such as Aluminium chloride, Ferric sulphate and Tannic acid on the shear bond strength of self-adhesive resin luting agent. Material and Methods: The buccal surfaces of extracted premolars were flattened to expose the dentine. The teeth were then randomly divided into four groups. In Group I Aluminium Chloride was applied on the flattened dentinal surface, in Group II Ferric Sulphate was applied to exposed dentin surface, in Group III tannic acid was applied on to the dentinal surface, and the control group, i.e. Group IV was rinsed with saline. After the surface treatment, all the teeth were air dried. Then a predetermined dimension of RelyX™ U200 self-adhesive resin cement was bonded to the pretreated dentin surfaces. The samples were then stored under 37 0 C in distilled water for 24 hours under 100 % humidity. Following this each sample was tested for shear bond strength with an Instron testing machine at a crosshead speed of 1mm/min. Results: There was significant difference in the shear bond strength of control and tannic acid contaminated group ( p <0.05), whereas there was no significant differences between the shear bond strength between control and aluminium chloride and ferric sulphate groups ( p >0.05). Conclusions: The usage of haemostatic agent can negatively affect the bond strength of self-adhesive resin cement (Rely X) on to the dentin surface. As per the study Tannic acid significantly weakened the bond between the self- adhesive resin and dentin