Anti-Judaic writings of the Late Antiquity include traditional accusations of the adversus Iudaeos literature, as it happens in Isidore of Sevilla¿s works, especiallyin the De fide catholica contra Iudaeos, the first antijewish apology in the Iberian Peninsula and the main source of this polemic in the following centuries. The bishop of Seville assumes an exegetical tradition that repeats the same topoi and arguments that can be observed in the first antijewish polemicists: their obstinacy, blindness and deafness for not acknowledging Jesus Christ as the Messiah; the emptiness of the Jewish laws as circumcision and sabbath; the deicide accusation; the divine punishment as a result of their acts. In this article I am going to compare the topics and arguments of Isidore against Jews with some representative works of the anti-Judaic literature of the first christianity in the Western Roman Empire: the Adversus Iudaeos of Tertullian and Augustine and the passages of this one subject-matter of two works, Divinae Institutiones of Lactantius and Apotheosis of Prudentius. Isidore of Seville continues the steps of his predecessors, who interpreted characters, events and institutions of the Old Testament in accordance with New Testament.