NAGIOS: RODERIC FUNCIONANDO

Genome-Wide SNP-genotyping array to study the evolution of the human pathogen Vibrio vulnificus Biotype 3

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Genome-Wide SNP-genotyping array to study the evolution of the human pathogen Vibrio vulnificus Biotype 3

dc.contributor.author	Raz, Nili
dc.contributor.author	Danin-Poleg, Yael
dc.contributor.author	Hayman, Ryan B.
dc.contributor.author	Bar-On, Yudi
dc.contributor.author	Linetsky, Alex
dc.contributor.author	Shmoish, Michael
dc.contributor.author	Sanjuán Caro, Eva
dc.contributor.author	Amaro González, Carmen
dc.contributor.author	Walt, David R.
dc.contributor.author	Kashi, Yechezkel
dc.date.accessioned	2015-11-16T12:26:16Z
dc.date.available	2015-11-16T12:26:16Z
dc.date.issued	2014
dc.identifier.citation	Raz, Nili Danin-Poleg, Yael Hayman, Ryan B. Bar-On, Yudi Linetsky, Alex Shmoish, Michael Sanjuán Caro, Eva Amaro González, Carmen Walt, David R. Kashi, Yechezkel 2014 Genome-Wide SNP-genotyping array to study the evolution of the human pathogen Vibrio vulnificus Biotype 3 Plos One 9 12 1 21
dc.identifier.uri	http://hdl.handle.net/10550/48208
dc.description.abstract	Vibrio vulnificus is an aquatic bacterium and an important human pathogen. Strains Of V. vulnificus are classified into three different biotypes. The newly emerged biotype 3 has been found to be clonal and restricted to Israel. In the family Vibrionaceae , horizontal gene transfer is the main mechanism responsible for the emergence of new pathogen groups. To better understand the evolution of the bacterium, and in particular to trace the evolution of biotype 3, we performed genome-wide SNP genotyping of 254 clinical and environmental V. vulnificus isolates with worldwide distribution recovered over a 30-year period, representing all phylogeny groups. A custom single-nucleotide polymorphism (SNP) array implemented on the Illumina GoldenGate platform was developed based on 570 SNPs randomly distributed throughout the genome. In general, the genotyping results divided the V. vulnificus species into three main phylogenetic lineages and an additional subgroup, clade B, consisting of environmental and clinical isolates from Israel. Data analysis suggested that 69% of biotype 3 SNPs are similar to SNPs from clade B, indicating that biotype 3 and clade B have a common ancestor. The rest of the biotype 3 SNPs were scattered along the biotype 3 genome, probably representing multiple chromosomal segments that may have been horizontally inserted into the clade B recipient core genome from other phylogroups or bacterial species sharing the same ecological niche. Results emphasize the continuous evolution of V. vulnificus and support the emergence of new pathogenic groups within this species as a recurrent phenomenon. Our findings contribute to a broader understanding of the evolution of this human pathogen.
dc.language.iso	eng
dc.relation.ispartof	Plos One, 2014, vol. 9, num. 12, p. 1-21
dc.subject	Bacteris patògens
dc.title	Genome-Wide SNP-genotyping array to study the evolution of the human pathogen Vibrio vulnificus Biotype 3
dc.type	journal article	es_ES
dc.date.updated	2015-11-16T12:26:16Z
dc.identifier.doi	10.1371/journal.pone.0114576
dc.identifier.idgrec	104042
dc.rights.accessRights	open access	es_ES