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Increased nuclear β-catenin expression in oral potentially malignant lesions: a marker of epithelial dysplasia

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Increased nuclear β-catenin expression in oral potentially malignant lesions: a marker of epithelial dysplasia

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dc.contributor.author Reyes Rojas, Montserrat es
dc.contributor.author Rojas Alcayaga, Gonzalo es
dc.contributor.author Maturana Ramírez, Andrea es
dc.contributor.author Aitken Saavedra, Juan es
dc.contributor.author Rojas, Carolina es
dc.contributor.author Ortega Pinto, Ana Verónica es
dc.date.accessioned 2015-11-23T13:40:23Z
dc.date.available 2015-11-23T13:40:23Z
dc.date.issued 2015 es
dc.identifier.citation Reyes Rojas, Montserrat ; Rojas Alcayaga, Gonzalo ; Maturana Ramírez, Andrea ; Aitken Saavedra, Juan ; Rojas, Carolina ; Ortega Pinto, Ana Verónica. Increased nuclear β-catenin expression in oral potentially malignant lesions: a marker of epithelial dysplasia. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2015, Vol. 20, No. 5: 6- es
dc.identifier.uri http://hdl.handle.net/10550/48343
dc.description.abstract Background: Deregulation of β-catenin is associated with malignant transformation; however, its relationship with potentially malignant and malignant oral processes is not fully understood. The aim of this study was to determine and compare the nuclear β-catenin expression in oral dysplasia and oral squamous cell carcinoma (OSCC). Material and Methods: Cross sectional study. Immunodetection of β-catenin was performed on 72 samples, with the following distribution: 21 mild dysplasia, 12 moderate dysplasia, severe dysplasia 3, 36 OSCC including 19 well differentiated, 15 moderately differentiated and 2 poorly differentiated. Through microscopic observation the number of positive cells per 1000 epithelial cells was counted. For the statistical analysis, the Kruskal Wallis test was used. Results: Nuclear expression of β-catenin was observed in all samples with severe and moderate dysplasia, with a median of 267.5, in comparison to mild dysplasia whose median was 103.75. Only 10 samples (27.7%) with OSCC showed nuclear expression, with statistically significant differences between groups ( p < 0.05). Conclusions: Our results are consistent with most of the reports which show increased presence of β-catenin in severe and moderate dysplasia compared to mild dysplasia; however the expression of nuclear β-catenin decreased after starting the invasive neoplastic process. This suggests a role for this protein in the progression of dysplasia and early malignant transformation to OSCC. Immunodetection of β-catenin could be a possible immune marker in the detection of oral dysplasia en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Increased nuclear β-catenin expression in oral potentially malignant lesions: a marker of epithelial dysplasia es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES
dc.identifier.url http://dialnet.unirioja.es/servlet/citart?info=link&codigo=5219414&orden=0 es

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