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Apixaban and oral implications

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Apixaban and oral implications

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dc.contributor.author López Galindo, Mónica Paula es
dc.contributor.author Bagán Sebastián, José Vicente es
dc.date.accessioned 2015-11-23T13:53:22Z
dc.date.available 2015-11-23T13:53:22Z
dc.date.issued 2015 es
dc.identifier.citation López Galindo, Mónica Paula ; Bagán Sebastián, José Vicente. Apixaban and oral implications. En: Journal of Clinical and Experimental Dentistry, 2015, Vol. 7, No. 4: 528-534 es
dc.identifier.uri http://hdl.handle.net/10550/48363
dc.description.abstract Background: Thrombotic disorders remain a leading cause of death in the Western world, and in this regard a number of anticoagulation treatment have been used, including heparins, fondaparinux, vitamin K antagonists (warfarin, acenocoumarol), and new oral anticoagulants such as apixaban. For years there has been great controversy regarding the use of anticoagulants in planning dental treatments that imply bleeding. The main concerns about using new oral anticoagulants in invasive dental procedures are bleeding due to the lack of an antidote, and the thrombotic risk of the disease for which anticoagulation was indicated in the first place. Material and Methods: A literature search was conducted through May 2014 using the keyword “apixaban” for publications in the ISI Web of Knowledge. The search was extended to other databases (PubMed, Scopus and the Cochrane Library). Results: Based on the results of the different studies, apixaban seems to be a good alternative to conventional anticoagulation and a reasonable treatment option, though its main and most common adverse effect is bleeding. Dose adjustment is needed in some patients, though regular laboratory monitoring is not required. The use of the drug in different patient populations will define its final indications and doses. Conclusions: Regarding the use of apixaban in the dental setting, there is a compelling need for further clinical studies in order to establish more evidence-based guidelines for patients requiring antithrombotic treatment en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Apixaban and oral implications es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.idgrec 113036
dc.type.hasVersion VoR es_ES

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