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A sequence motif enriched in regions bound by the Drosophila dosage compensation complex

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A sequence motif enriched in regions bound by the Drosophila dosage compensation complex

dc.contributor.author	Gallach Caballero, Miguel
dc.contributor.author	Arnau Llombart, Vicente
dc.contributor.author	Aldecoa, Rodrigo
dc.contributor.author	Marín Lozano, Ignacio
dc.date.accessioned	2015-12-16T10:14:33Z
dc.date.available	2015-12-16T10:14:33Z
dc.date.issued	2010
dc.identifier.citation	Gallach Caballero, Miguel Arnau Llombart, Vicente Aldecoa, Rodrigo Marín Lozano, Ignacio 2010 A sequence motif enriched in regions bound by the Drosophila dosage compensation complex Bmc Genomics 11 169 1 14
dc.identifier.uri	http://hdl.handle.net/10550/49519
dc.description.abstract	Background: In Drosophila melanogaster, dosage compensation is mediated by the action of the dosage compensation complex (DCC). How the DCC recognizes the fly X chromosome is still poorly understood. Characteristic sequence signatures at all DCC binding sites have not hitherto been found. Results: In this study, we compare the known binding sites of the DCC with oligonucleotide profiles that measure the specificity of the sequences of the D. melanogaster X chromosome. We show that the X chromosome regions bound by the DCC are enriched for a particular type of short, repetitive sequences. Their distribution suggests that these sequences contribute to chromosome recognition, the generation of DCC binding sites and/or the local spreading of the complex. Comparative data indicate that the same sequences may be involved in dosage compensation in other Drosophila species. Conclusions: These results offer an explanation for the wild-type binding of the DCC along the Drosophila X chromosome, contribute to delineate the forces leading to the establishment of dosage compensation and suggest new experimental approaches to understand the precise biochemical features of the dosage compensation system.
dc.language.iso	eng
dc.relation.ispartof	Bmc Genomics, 2010, vol. 11, num. 169, p. 1-14
dc.subject	Genètica
dc.subject	Genòmica
dc.subject	Expressió genètica
dc.title	A sequence motif enriched in regions bound by the Drosophila dosage compensation complex
dc.type	journal article	es_ES
dc.date.updated	2015-12-16T10:14:33Z
dc.identifier.doi	10.1186/1471-2164-11-169
dc.identifier.idgrec	064868
dc.rights.accessRights	open access	es_ES