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A web application for the unspecific detection of differentially expressed DNA regions in strand-specific expression data

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A web application for the unspecific detection of differentially expressed DNA regions in strand-specific expression data

dc.contributor.author	Juanes, José M.
dc.contributor.author	Miguel, Ana
dc.contributor.author	Morales, Lucas J.
dc.contributor.author	Pérez Ortín, José Enrique
dc.contributor.author	Arnau Llombart, Vicente
dc.date.accessioned	2015-12-22T12:15:37Z
dc.date.available	2016-10-01T04:45:05Z
dc.date.issued	2015
dc.identifier.citation	Juanes, José M. Miguel, Ana Morales, Lucas J. Pérez Ortín, José Enrique Arnau Llombart, Vicente 2015 A web application for the unspecific detection of differentially expressed DNA regions in strand-specific expression data Bioinformatics 31 19 3228 3230
dc.identifier.uri	http://hdl.handle.net/10550/49731
dc.description.abstract	Genomic technologies allow laboratories to produce large-scale data sets, either through the use of next-generation sequencing or microarray platforms. To explore these data sets and obtain máximum value from the data, researchers view their results alongside all the known features of a given reference genome. To study transcriptional changes that occur under a given condition, researchers search for regions of the genome that are differentially expressed between different experimental conditions. In order to identify these regions several algorithms have been developed over the years, along with some bioinformatic platforms that enable their use. However, currently available applications for comparative microarray analysis exclusively focus on changes in gene expression within known transcribed regions of predicted proteincoding genes, the changes that occur in non-predictable genetic elements, such as non-coding RNAs. Here, we present a web application for the visualization of strand-specific tiling microarray or next-generation sequencing data that allows customized detection of differentially expressed regions all along the genome in an unspecific manner, that allows identification of all RNA sequences, predictable or not
dc.language.iso	eng
dc.relation.ispartof	Bioinformatics, 2015, vol. 31, num. 19, p. 3228-3230
dc.subject	Genètica
dc.subject	Expressió genètica
dc.subject	Genòmica
dc.subject	ADN
dc.title	A web application for the unspecific detection of differentially expressed DNA regions in strand-specific expression data
dc.type	journal article	es_ES
dc.date.updated	2015-12-22T12:15:37Z
dc.identifier.doi	10.1093/bioinformatics/btv343
dc.identifier.idgrec	107424
dc.rights.accessRights	open access	es_ES