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Wired for motherhood: induction of maternal care but not maternal aggression in virgin female CD1 mice

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Wired for motherhood: induction of maternal care but not maternal aggression in virgin female CD1 mice

dc.contributor.author	Martín-Sánchez, A.
dc.contributor.author	Valera-Marín, G.
dc.contributor.author	Hernández Martínez, Adoración
dc.contributor.author	Lanuza Navarro, Enrique
dc.contributor.author	Martínez-García, Fernando
dc.contributor.author	Agustín-Pavón, Carmen
dc.date.accessioned	2015-12-22T13:12:37Z
dc.date.available	2015-12-22T13:12:37Z
dc.date.issued	2015
dc.identifier.citation	Martín-Sánchez, A.; Valera-Marín, G.; Hernández Martínez, Adoración; Lanuza Navarro, Enrique; Martínez-García, Fernando; Agustín-Pavón, Carmen (2015) Wired for motherhood: induction of maternal care but not maternal aggression in virgin female CD1 mice Frontiers In Behavioral Neuroscience 9 197 1 12
dc.identifier.uri	http://hdl.handle.net/10550/49733
dc.description.abstract	Virgin adult female mice display nearly spontaneous maternal care towards foster pups after a short period of sensitization. This indicates that maternal care is triggered by sensory stimulation provided by the pups and that its onset is largely independent on the physiological events related to gestation, parturition and lactation. Conversely, the factors influencing maternal aggression are poorly understood. In this study, we sought to characterize two models of maternal sensitization in the outbred CD1 strain. To do so, a group of virgin females (godmothers) were exposed to continuous cohabitation with a lactating dam and their pups from the moment of parturition, whereas a second group (pup-sensitized females), were exposed 2 h daily to foster pups. Both groups were tested for maternal behavior on postnatal days 2-4. Godmothers expressed full maternal care from the first test. Also, they expressed higher levels of crouching than dams. Pup-sensitized females differed from dams in all measures of pup-directed behavior in the first test, and expressed full maternal care after two sessions of contact with pups. However, both protocols failed to induce maternal aggression toward a male intruder after full onset of pup-directed maternal behavior, even in the presence of pups. Our study confirms that adult female mice need a short sensitization period before the onset of maternal care. Further, it shows that pup-oriented and non-pup-oriented components of maternal behavior are under different physiological control. We conclude that the godmother model might be useful to study the physiological and neural bases of the maternal behavior repertoire.
dc.language.iso	eng
dc.relation.ispartof	Frontiers In Behavioral Neuroscience, 2015, vol. 9, num. 197, p. 1-12
dc.subject	Neurociències
dc.subject	Biologia experimental
dc.title	Wired for motherhood: induction of maternal care but not maternal aggression in virgin female CD1 mice
dc.type	journal article	es_ES
dc.date.updated	2015-12-22T13:12:37Z
dc.identifier.doi	10.3389/fnbeh.2015.00197
dc.identifier.idgrec	107440
dc.rights.accessRights	open access	es_ES