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Inmunohistochemical detection of mastocytes in tissue from patients with actinic prurigo

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Inmunohistochemical detection of mastocytes in tissue from patients with actinic prurigo

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dc.contributor.author Martínez Luna, Eduwiges es
dc.contributor.author Bologna-Molina, Ronell es
dc.contributor.author Mosqueda Taylor, Adalberto es
dc.contributor.author Cuevas González, Juan Carlos es
dc.contributor.author Rodríguez Lobato, Erika es
dc.contributor.author Martínez Velasco, María Abril es
dc.contributor.author Vega Memije, María Elisa es
dc.date.accessioned 2016-01-20T12:12:23Z
dc.date.available 2016-01-20T12:12:23Z
dc.date.issued 2015 es
dc.identifier.citation Martínez Luna, Eduwiges ; Bologna-Molina, Ronell ; Mosqueda Taylor, Adalberto ; Cuevas González, Juan Carlos ; Rodríguez Lobato, Erika ; Martínez Velasco, María Abril ; Vega Memije, María Elisa. Inmunohistochemical detection of mastocytes in tissue from patients with actinic prurigo. En: Journal of Clinical and Experimental Dentistry, 2015, Vol. 7, No. 5: 656-659 es
dc.identifier.uri http://hdl.handle.net/10550/50183
dc.description.abstract Background: Actinic prurigo (AP) is a type of photodermatosis, the pathophysiology of which has not been determined. AP has been suggested to be a hypersensitivity reaction to the presence of eosinophils and the local production of IgE. Material and Methods: Descriptive study, using paraffin blocks of tissue that have been diagnosed with AP from the Dermopathology department, Hospital General Dr. Manuel Gea González. In 66 blocks from 63 patients, eosinophils were identified by hematoxylin and eosin staining, and mastocytes were labeled by immunohistochemistry. Three random microphotographs (40x) were used, and cell counts were calculated as the mean count in the 3 microphotographs. Results: Forty cases (63.5%) were female, and 23 (36.5%) were male. The mean age was 26.49 ±14.09 years; regarding the evolution time of the disease, the average was 11.93 years ±11.39. In 38 of 63 cases (60%), the lip, skin, and conjunctiva were affected clinically. In 22 of 63 cases (34%), AP cheilitis was the sole manifestation, and in 4 of 63 cases (6%), there were lesions in the skin and conjunctiva. The mean eosinophil count was 9 per case, the average number of mastocytes/field was 28.48 (range 0 to 66) Kruskal-W allis p =0.001. Conclusions: There are elements in AP that mediate the reaction of hypersensitivity type IV b, necessitating the identification of triggering factors. en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Inmunohistochemical detection of mastocytes in tissue from patients with actinic prurigo es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES

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