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Synchronous metastatic cutaneous squamous cell carcinoma and chronic lymphocytic leukaemia/small lymphocytic lymphoma in a cervical lymph node: case report of an unusual event

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Synchronous metastatic cutaneous squamous cell carcinoma and chronic lymphocytic leukaemia/small lymphocytic lymphoma in a cervical lymph node: case report of an unusual event

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dc.contributor.author dos Santos, Harim Tavares es
dc.contributor.author Andrade, Bruno Augusto Benevenuto de es
dc.contributor.author Filho, Edson Robles Castilla es
dc.contributor.author Altemani, Albina es
dc.date.accessioned 2016-01-20T12:12:23Z
dc.date.available 2016-01-20T12:12:23Z
dc.date.issued 2015 es
dc.identifier.citation dos Santos, Harim Tavares ; Andrade, Bruno Augusto Benevenuto de ; Filho, Edson Robles Castilla ; Altemani, Albina. Synchronous metastatic cutaneous squamous cell carcinoma and chronic lymphocytic leukaemia/small lymphocytic lymphoma in a cervical lymph node: case report of an unusual event. En: Journal of Clinical and Experimental Dentistry, 2015, Vol. 7, No. 5: 660-664 es
dc.identifier.uri http://hdl.handle.net/10550/50184
dc.description.abstract The synchronous occurrence of two different neoplasias is an uncommon event, which may arise between tumors originating in the same organ or in cancer-to-cancer metastasis. We report a rare case of chronic lymphocytic leukaemia / small lymphocytic lymphoma associated with a cutaneous metastatic squamous cell carcinoma in a cervical lymph node. In the affected lymph node, it was observed an effacement of the normal architecture by neoplastic lymphocytes and it was noted the presence of neoplastic invasive epithelial islands. Immunohistochemical analysis demonstrated that lymphocytic proliferation was positive for CD20, CD5, CD23 and Kappa, and negative for CD3, CD10, Cyclin D1 and Lambda. The morphological and immunohistochemical profile lead to a phenotype of B-cell chronic lymphocytic leukaemia / small lymphocytic lymphoma. The epithelial cells were positive for CK5, thus rendering the diagnosis of synchronous metastatic cutaneous squamous cell carcinoma and chronic lymphocytic leukaemia/small lymphocytic lymphoma. Literature supports the poor prognosis in cases that present coexistence of squamous cell carcinoma and chronic lymphocytic leukaemia / small lymphocytic lymphoma. Thus, it is necessary to be aware about this unusual finding in order to provide specific treatment. en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Synchronous metastatic cutaneous squamous cell carcinoma and chronic lymphocytic leukaemia/small lymphocytic lymphoma in a cervical lymph node: case report of an unusual event es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES

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