NAGIOS: RODERIC FUNCIONANDO

The cellular growth rate controls overall mRNA turnover, and modulates either transcription or degradation rates of particular gene regulons

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

The cellular growth rate controls overall mRNA turnover, and modulates either transcription or degradation rates of particular gene regulons

dc.contributor.author	García Martínez, José
dc.contributor.author	Delgado Ramos, Lidia
dc.contributor.author	Ayala Gallego, Guillermo
dc.contributor.author	Pelechano García, Vicente José
dc.contributor.author	Medina Salas, Daniel Alejandro
dc.contributor.author	Carrasco, Fany
dc.contributor.author	González, Ramón
dc.contributor.author	Andrés-León, Eduardo
dc.contributor.author	Steinmetz, Lars
dc.contributor.author	Warringer, Jonas
dc.contributor.author	Chávez, Sebastián
dc.contributor.author	Pérez Ortín, José Enrique
dc.date.accessioned	2016-03-08T13:27:32Z
dc.date.available	2016-03-08T13:27:32Z
dc.date.issued	2015
dc.identifier.citation	García Martínez, José Delgado Ramos, Lidia Ayala Gallego, Guillermo Pelechano García, Vicente José Medina Salas, Daniel A. Carrasco, Fany González, Ramón Andrés-León, Eduardo Steinmetz, Lars Warringer, Jonas Chávez, Sebastián Pérez Ortín, José Enrique 2015 The cellular growth rate controls overall mRNA turnover, and modulates either transcription or degradation rates of particular gene regulons Nucleic Acids Research 2015 1 16
dc.identifier.uri	http://hdl.handle.net/10550/51801
dc.description.abstract	We analyzed 80 different genomic experiments, and found a positive correlation between both RNA polymerase II transcription and mRNA degradation with growth rates in yeast. Thus, in spite of the marked variation in mRNA turnover, the total mRNA concentration remained approximately constant. Some genes, however, regulated their mRNA concentration by uncoupling mRNA stability from the transcription rate. Ribosome-related genes modulated their transcription rates to increase mRNA levels under fast growth. In contrast, mitochondria-related and stress-induced genes lowered mRNA levels by reducing mRNA stability or the transcription rate, respectively. We also detected these regulations within the heterogeneity of a wild-type cell population growing in optimal conditions. The transcriptomic analysis of sorted microcolonies confirmed that the growth rate dictates alternative expression programs by modulating transcription and mRNA decay. The regulation of overall mRNA turnover keeps a constant ratio between mRNA decay and the dilution of [mRNA] caused by cellular growth. This regulation minimizes the indiscriminate transmission of mRNAs from mother to daughter cells, and favors the response capacity of the latter to physiological signals and environmental changes. We also conclude that, by uncoupling mRNA synthesis from decay, cells control the mRNA abundance of those gene regulons that characterize fast and slow growth.
dc.language.iso	eng
dc.relation.ispartof	Nucleic Acids Research, 2015, vol. 2015, p. 1-16
dc.subject	Genètica molecular
dc.subject	RNA
dc.subject	Transcripció genètica
dc.title	The cellular growth rate controls overall mRNA turnover, and modulates either transcription or degradation rates of particular gene regulons
dc.type	journal article	es_ES
dc.date.updated	2016-03-08T13:27:32Z
dc.identifier.doi	10.1093/nar/gkv1512
dc.identifier.idgrec	108979
dc.rights.accessRights	open access	es_ES