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TlR expression profile of human gingival margin-derived stem progenitor cells

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TlR expression profile of human gingival margin-derived stem progenitor cells

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dc.contributor.author Fawzy-El-Sayed, Karim es
dc.contributor.author Mekhemar, Mohamed es
dc.contributor.author Adam-Klages, Sabine es
dc.contributor.author Kabelitz, Dietrich es
dc.contributor.author Dörfer, Christof es
dc.date.accessioned 2016-04-06T12:31:13Z
dc.date.available 2016-04-06T12:31:13Z
dc.date.issued 2016 es
dc.identifier.citation Fawzy-El-Sayed, Karim ; Mekhemar, Mohamed ; Adam-Klages, Sabine ; Kabelitz, Dietrich ; Dörfer, Christof. TlR expression profile of human gingival margin-derived stem progenitor cells. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2016, Vol. 21, No. 1: 30- es
dc.identifier.uri http://hdl.handle.net/10550/52013
dc.description.abstract Background: Gingival margin-derived stem/progenitor cells (G-MSCs) show remarkable periodontal regenerative potential in vivo. During regeneration, G-MSCs may interact with their inflammatory environment via toll-likereceptors (TLRs). The present study aimed to depict the G-MSCs TLRs expression profile. Material and Methods: Cells were isolated from free gingival margins, STRO-1-immunomagnetically sorted and seeded to obtain single colony forming units (CFUs). G-MSCs were characterized for CD14, CD34, CD45, CD73, CD90, CD105, CD146 and STRO-1 expression, and for multilineage differentiation potential. Following G-MSCs’ incubation in basic or inflammatory medium (IL-1β, IFN-γ, IFN-α, TNF-α) a TLR expression profile was generated. Results: G-MSCs showed all stem/progenitor cells’ characteristics. In basic medium G-MSCs expressed TLRs 1, 2, 3, 4, 5, 6, 7, and 10. The inflammatory medium significantly up-regulated TLRs 1, 2, 4, 5, 7 and 10 and diminished TLR 6 (p≤0.05, Wilcoxon-Signed-Ranks-Test). Conclusions: The current study describes for the first time the distinctive TLRs expression profile of G-MSCs under uninflamed and inflamed conditions. en_US
dc.relation es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title TlR expression profile of human gingival margin-derived stem progenitor cells es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES

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