NAGIOS: RODERIC FUNCIONANDO

Apoptosis and apoptotic pathway in actinic prurigo by immunohistochemistry

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Apoptosis and apoptotic pathway in actinic prurigo by immunohistochemistry

Mostra el registre parcial de l'element

dc.contributor.author Cuevas González, Juan Carlos es
dc.contributor.author Vega Memije, María Elisa es
dc.contributor.author Garcia-Vazquez, Francisco Javier es
dc.contributor.author Rodríguez Lobato, Erika es
dc.contributor.author Farfan-Morales, José-Eduardo es
dc.date.accessioned 2016-04-06T12:31:13Z
dc.date.available 2016-04-06T12:31:13Z
dc.date.issued 2016 es
dc.identifier.citation Cuevas González, Juan Carlos ; Vega Memije, María Elisa ; Garcia-Vazquez, Francisco Javier ; Rodríguez Lobato, Erika ; Farfan-Morales, José-Eduardo. Apoptosis and apoptotic pathway in actinic prurigo by immunohistochemistry. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2016, Vol. 21, No. 1: 53- es
dc.identifier.uri http://hdl.handle.net/10550/52016
dc.description.abstract Background: Actinic prurigo (AP) is an idiopathic photodermatosis, this entity requires exposure to UV-B and -A to develop lesions. Apoptosis is a physiological death program that can be initiated by a permanently active mechanism (extrinsic pathway) or irreparable damage (intrinsic pathway). Material and methods: Descriptive study, the sample size comprised 64 paraffin blocks of tissue with a diagnosis of AP. In H&E-stained slides, the diagnosis of AP was corroborated, and 1-µm-thick sections were processed for immunohistochemistry (IHC). A database was constructed with SPSS version 20, Inc., Chicago, IL, USA, and descriptive statistics were analyzed by X2 test and comparison of means. Results: A total of 64 cases were processed, of which 40 (62.5%) were cheilitis AP and 24 (37.5%) were AP in the skin. Of the 40 cheilitis samples, 27 were positive for Bcl-2 and caspase 3 (67.5%), p53 was expressed in 30 (75%). Of the skin lesions, p53 and caspase 3 were expressed in 18 of 24 cases (75%), and 13 were positive for Bcl-2 (54%). Conclusions: We propose that apoptosis is the last step in the type IV subtype a-b hypersensitivity responseactivation of the intrinsic pathway indicates that external factors, such as UV-A and -B are the trigger. en_US
dc.relation es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Apoptosis and apoptotic pathway in actinic prurigo by immunohistochemistry es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES

Visualització       (2.629Mb)

Aquest element apareix en la col·lecció o col·leccions següent(s)

Mostra el registre parcial de l'element

Cerca a RODERIC

Cerca avançada

Visualitza

Estadístiques