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Management of oral Graft versus Host Disease with topical agents: a systematic review

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Management of oral Graft versus Host Disease with topical agents: a systematic review

dc.contributor.author	Albuquerque, Rui	es
dc.contributor.author	Khan, Zahid	es
dc.contributor.author	Poveda, Ana	es
dc.contributor.author	Higham, Jonathan	es
dc.contributor.author	Richards, Andrea	es
dc.contributor.author	Monteiro, Luís Silva	es
dc.contributor.author	Jane Salas, Enric	es
dc.contributor.author	López López, José	es
dc.contributor.author	Warnakulasuriya, Saman	es
dc.date.accessioned	2016-04-06T12:31:14Z
dc.date.available	2016-04-06T12:31:14Z
dc.date.issued	2016	es
dc.identifier.citation	Albuquerque, Rui ; Khan, Zahid ; Poveda, Ana ; Higham, Jonathan ; Richards, Andrea ; Monteiro, Luís Silva ; Jane Salas, Enric ; López López, José ; Warnakulasuriya, Saman. Management of oral Graft versus Host Disease with topical agents: a systematic review. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2016, Vol. 21, No. 1: 72-	es
dc.identifier.uri	http://hdl.handle.net/10550/52020
dc.description.abstract	Background: Oral Graft-versus-Host Disease (oGvHD) is a common complication of haematopoietic stem cell transplantation. Choosing the right topical application to be used intra orally can be a challenge. Consequently, the aim of this work is to review the effectiveness and safety of topical agents currently used in the management of the inflammatory mucosal lesions encountered in oGVHD. Material and Methods: We carried out electronic searches of publications up to May 2015 of the databases Pubmed, National Library of Medicine’s Medline, Embase and the Cochrane Central Register of Controlled Clinical trials to identify potentially relevant studies (keywords: “oral”, “graft”, “versus”, “host”, “disease” and “treatment”). The main inclusion criterion was the reported use of a topical agent which was not intentionally swallowed when used for the treatment of oGVHD. A 3-point grading system, described by the Swedish Council on Technology Assessment in Health Care and the Centre for Reviews and Dissemination, University of York, was used to rate the methodological quality of the papers. Results: From the 902 entries identified in the search, 7 studies qualifying for inclusion were analysed. Overall, there is limited evidence with regards to the effectiveness of topical steroids for oGVHD. However, the studies showed some effect of Budesonide alone and when combined with dexamethasone. Topical tacrolimus also appears to have some effect and clobetasol propionate mouthwash had a significantly better clinical response than dexamethasone mouthwash in treating oGVHD. Conclusions: As the number of clinical trials conducted is limited, there is little evidence to support the use of topical therapies to treat the inflammatory mucosal lesions found in oGVHD. High quality randomised control trials are needed in order to measure the effectiveness of any topical application for the treatment of the inflammatory mucosal lesions found in oGVHD.	en_US
dc.relation		es
dc.subject	Odontología	es
dc.subject	Ciencias de la salud	es
dc.title	Management of oral Graft versus Host Disease with topical agents: a systematic review	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.type.hasVersion	VoR	es_ES