Haemostasis is a mechanism that, through different interdependent biologic processes, has the purpose of ensuring the integrity and permeability of the circulatory system. Hemostasis term means prevention the loss of blood. Interventions or treatments in the oral cavity, in particular those with a possibility of bleeding, represent a risk for patients with disorders of hemostasis. Prevention is the key to avoid bleeding complications after oral surgical procedures and therefore it is essential a detailed medical history of the patient. The appropriate diagnosis and treatment in patients with disorders of hemostasis, depends directly in the understanding of hemostasis standard mechanisms. Emphasising not only the importance of a thoughtful insight into these mechanisms, but also of the existing analysis that study them. This paper makes a synthesis of the general aspects of inherited coagulation disorders (Von Willebrand disease and Hemophilia A and B) as well as of the alterations on platelets consequence of the use of certain medication (antiplatelet and anticoagulant drugs), and their dental management.