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Sonoporation, a redefined ultrasound modality as therapeutic aid: a review.

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Sonoporation, a redefined ultrasound modality as therapeutic aid: a review.

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dc.contributor.author Sheikh, Soheyl es
dc.contributor.author Pallagatti, Shambulingappa es
dc.contributor.author Singh, Balwinder es
dc.contributor.author Puri, Nidhi es
dc.contributor.author Singh, Ravinder es
dc.contributor.author Kalucha, Aman es
dc.date.accessioned 2016-06-20T07:13:25Z
dc.date.available 2016-06-20T07:13:25Z
dc.date.issued 2011 es
dc.identifier.citation Sheikh, Soheyl ; Pallagatti, Shambulingappa ; Singh, Balwinder ; Puri, Nidhi ; Singh, Ravinder ; Kalucha, Aman. Sonoporation, a redefined ultrasound modality as therapeutic aid: a review.. En: Journal of Clinical and Experimental Dentistry, 2011, Vol. 3, No. 3: 228-234 es
dc.identifier.uri http://hdl.handle.net/10550/54121
dc.description.abstract Traditionally a diagnostic modality, ultrasound is emerging as a promising tool for non-invasive therapy, drug delivery, and gene therapy. The ultrasound is a mechanical wave energy generated in a medium as oscillating pressure in space and time at frequencies above 20 kHz, beyond the audible range. The ultrasound exposure generates bioeffects resulting in tissue heating, shear stress, and cavitation, which have been exploited for therapeutic applications. Ultrasound cavitation, enhanced by injected micro bubbles, perturbs cell membrane structures to cause sonoporation and increases the permeability to bioactive materials. Ultrasound-mediated gene delivery has been applied to heart, blood vessel, lung, kidney, muscle, head and neck tumour with enhanced gene transfection efficiency. The genes can be incorporated into microbubbles which in turn can target a specific disease site. Local drug delivery ensures sufficient drug concentration at the diseased region while limiting toxicity for healthy tissues. Nevertheless, it has only recently become popular as a technique to enhance drug release from drug delivery systems. This review presents the main findings in the field of sonoporation, namely drug delivery, gene delivery and DNA transfer. en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Sonoporation, a redefined ultrasound modality as therapeutic aid: a review. es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES

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