Objective: To review the literature on ozone therapy in oral health, as assessed by different clinical and bacteriological parameters. Material and methods: A PubMed literature search was made using the key words “ozone dental”, and establishing as limits “randomized controlled trial” and “dental journal”. Thirteen articles were identified, with access to only 6 of them. Results: Four studies used ozone for the treatment of caries. One study examined its effect upon dental hypersensitivity, while another evaluated the efficacy of ozone as a tooth whitening technique. Five studies explored the bacteriological actions of ozone therapy in reference to different types of bacteria. Conclusion: The reviewed literature yields a number of studies describing a high antimicrobial potential of ozone therapy in different dental areas, though very few in vivo studies have evidenced the success of such treatment. Further studies are therefore needed in this field.