An immature tooth with pulpal necrosis and periapical pathology imposes a great difficulty to the endodontists. Endodontic treatment options for such teeth consist of conventional apexification procedure with and without apical barriers. Various materials have been tried as apical matrix in the past. This article demonstrates the newer concept of using platelet rich fibrin membrane as an apical matrix barrier for stabilization of MTA in root end apexification procedure. Platelet Rich Fibrin is an autologous fibrin matrix containing a large quantity of platelet and leukocyte cytokines, which enhance healing by release of growth factors. This case report represents successful management of a case of an immature mandibular second molar with single root and single c-shaped canal. The unusual canal morphology was diagnosed with the help of a CBCT scan. Faster periradicular healing and complete resolution of symptoms occurred with combined use of MTA and PRF membrane as an apical barrier