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Novel mutations in the voltage-gated sodium channel of pyrethroid-resistant Varroa destructor populations from the Southeastern USA

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Novel mutations in the voltage-gated sodium channel of pyrethroid-resistant Varroa destructor populations from the Southeastern USA

dc.contributor.author	González Cabrera, Joel
dc.contributor.author	Rodríguez Vargas, Sonia
dc.contributor.author	Davies, Thomas G. Emyr
dc.contributor.author	Field, Linda M.
dc.contributor.author	Schmehl, Daniel
dc.contributor.author	Ellis, James D.
dc.contributor.author	Krieger, Klemens
dc.contributor.author	Williamson, Martin S.
dc.date.accessioned	2016-07-05T17:52:22Z
dc.date.available	2016-07-05T17:52:22Z
dc.date.issued	2016
dc.identifier.citation	González Cabrera, Joel Rodríguez Vargas, Sonia Emyr Davies, T. G. Field, Linda M. Schmehl, Daniel Ellis, James D. Krieger, Klemens Williamson, Martin S. 2016 Novel mutations in the voltage-gated sodium channel of pyrethroid-resistant Varroa destructor populations from the Southeastern USA Plos One 11 5 e0155332
dc.identifier.uri	http://hdl.handle.net/10550/54403
dc.description.abstract	The parasitic mite Varroa destructor has a significant worldwide impact on bee colony health. In the absence of control measures, parasitized colonies invariably collapse within 3 years. The synthetic pyrethroids tau-fluvalinate and flumethrin have proven very effective at managing this mite within apiaries, but intensive control programs based mainly on one active ingredient have led to many reports of pyrethroid resistance. In Europe, a modification of leucine to valine at position 925 (L925V) of the V. destructor voltage-gated sodium channel was correlated with resistance, the mutation being found at high frequency exclusively in hives with a recent history of pyrethroid treatment. Here, we identify two novel mutations, L925M and L925I, in tau-fluvalinate resistant V. destructor collected at seven sites across Florida and Georgia in the Southeastern region of the USA. Using a multiplexed TaqMan® allelic discrimination assay, these mutations were found to be present in 98% of the mites surviving tau-fluvalinate treatment. The mutations were also found in 45% of the non-treated mites, suggesting a high potential for resistance evolution if selection pressure is applied. The results from a more extensive monitoring programme, using the Taqman® assay described here, would clearly help beekeepers with their decision making as to when to include or exclude pyrethroid control products and thereby facilitate more effective mite management programmes.
dc.language.iso	eng
dc.relation.ispartof	Plos One, 2016, vol. 11, num. 5, p. e0155332
dc.subject	Àcars
dc.subject	Abelles
dc.subject	Paràsits
dc.subject	Microbiologia
dc.title	Novel mutations in the voltage-gated sodium channel of pyrethroid-resistant Varroa destructor populations from the Southeastern USA
dc.type	journal article	es_ES
dc.date.updated	2016-07-05T17:52:22Z
dc.identifier.doi	10.1371/journal.pone.0155332
dc.identifier.idgrec	113388
dc.rights.accessRights	open access	es_ES