Objective: Studies on odontogenic tumors published from many parts of the world show a distinct geographic va- riation; however, there is little information available in the English-language literature on the relative frequency of odontogenic tumors in India. This retrospective study was designed to determine the relative frequency of odonto- genic tumors in an Indian population and compare them with various reports from other parts of the world. Study design: The histopathology records of the Department of Oral pathology and Microbiology of Government Dental College and Hospital, Mumbai were retrieved retrospectively within the period of January 2001 to March 2010. A total of 60 lesions classified as odontogenic tumors were reviewed. These were analyzed for age, gender, site of tumor and histopathologic typing. Criteria used were World Health Organization (WHO) classification 2005. The controversy still exists regarding the nature of odontogenic keratocyst or tumor, so it has not been included in this study. Results: A total of 60 cases of odontogenic tumors were reported in this period. The most frequent histological type was ameloblastoma (66.67%), followed by odontome (20%), adenomatoid odontogenic tumor (10%). In general, the odontogenic tumors showed a predilection for the mandible and the posterior regions of the jaws. Ameloblastomas occurred with a marked predilection for the mandible, while adenomatoid odontogenic tumor showed predi- lection for the maxilla, anterior regions of the jaws, and young females. Conclusion: Odontogenic tumors show a definite geographic variation. In our study, ameloblastomas were the most frequent odontogenic tumors, with distinct anatomic predilections