Generally natural rubber latex (NRL) allergy is detected after some exposition to the material. As NRL is com- monly found in different materials used daily in dental clinic, the allergy can be manifested in the pediatric dentistry clinic. The first clinical manifestation can be smooth but also severe, therefore it is important to know different manifestations and how to prevent them. Objective: Report two clinical cases of natural rubber latex allergy in children and to present the safety measures that must be taken during clinical assistance, as using metallic saliva ejector, vinyl gloves for the treatment procedures and as an option to rubber dam. Cases Report: Case 1- Patient presented body swellings after contact with latex. Case 2- Patient presented skin eruptions and urticaria after contact with balloons suggesting possible NRL allergy. Conclusions: The precautions must always be taken during the dental treatment of natural rubber latex allergic patients in order to achieve satisfactory results by avoiding dermatitis or even anaphylactic shock.