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Bisphosphonates, vitamin D, parathyroid hormone, and osteonecrosis of the jaw. Could there be a missing link?

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Bisphosphonates, vitamin D, parathyroid hormone, and osteonecrosis of the jaw. Could there be a missing link?

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dc.contributor.author Leizaola-Cardesa, Ignacio-Osoitz es
dc.contributor.author Aguilar Salvatierra, Antonio es
dc.contributor.author González Jaranay, Maximino es
dc.contributor.author Moreu Burgos, Gerardo es
dc.contributor.author Sala-Romero, María-José es
dc.contributor.author Gómez Moreno, Gerardo es
dc.date.accessioned 2016-07-26T11:54:37Z
dc.date.available 2016-07-26T11:54:37Z
dc.date.issued 2016 es
dc.identifier.citation Leizaola-Cardesa, Ignacio-Osoitz ; Aguilar Salvatierra, Antonio ; González Jaranay, Maximino ; Moreu Burgos, Gerardo ; Sala-Romero, María-José ; Gómez Moreno, Gerardo. Bisphosphonates, vitamin D, parathyroid hormone, and osteonecrosis of the jaw. Could there be a missing link?. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2016, : 236- es
dc.identifier.uri http://hdl.handle.net/10550/54747
dc.description.abstract It is estimated that over 190 million bisphosphonates have been prescribed worldwide. But this drug can produce adverse effects, of which osteonecrosis of the jaw and severe hypocalcemia are the most serious. It is evident that bisphosphonate administration affects multiple and diverse biochemical mediators related to bone metabolism. This review of literature investigates four basic parameters in patients treated with bisphosphonates - parathyroid hormone (PTH), bisphosphonates, vitamin D, calcium, and jaw osteonecrosis - which are fundamental for assessing bone metabolism and so the efficacy and correct use of the drug. The imbalances generated by vitamin D and calcium deficiencies, together with their multiple systemic repercussions, have been widely researched but the outcomes of these imbalances in relation to bisphosphonate administration are not well known, and some research has indicated that they may be associated with osteonecrosis of the jaw (ONJ). The present review set out to explain the functioning of bone metabolism, the importance of different chemical mediators, the imbalances produced by incorrect use of this drug, in order to forewarn against the possible relation of these parameters with ONJ, whose physiopathology remains unknown. Medical and dental clinics should keep detailed anamneses of the use of vitamin D and calcium supplements, as it is of vital importance to maintain their correct levels in blood, given that these are related to ONJ as well as other adverse effects; this procedure is also necessary in order to ensure the correct use of the drug. en_US
dc.relation es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Bisphosphonates, vitamin D, parathyroid hormone, and osteonecrosis of the jaw. Could there be a missing link? es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES

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