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Histopathological grading systems analysis of oral squamous cell carcinomas of young patients

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Histopathological grading systems analysis of oral squamous cell carcinomas of young patients

dc.contributor.author	Frare, Juliana-Cristina	es
dc.contributor.author	Sawazaki-Calone, Iris	es
dc.contributor.author	Ayroza Rangel, Ana Lúcia Carrinho	es
dc.contributor.author	Galvão Bueno, Alexandre	es
dc.contributor.author	Morais, Carlos-Floriano de	es
dc.contributor.author	Nagai, Hildebrando-Massahiro	es
dc.contributor.author	Kunz, Reno	es
dc.contributor.author	Lopes, Márcio Ajudarte	es
dc.date.accessioned	2016-07-26T11:58:24Z
dc.date.available	2016-07-26T11:58:24Z
dc.date.issued	2016	es
dc.identifier.citation	Frare, Juliana-Cristina ; Sawazaki-Calone, Iris ; Ayroza Rangel, Ana Lúcia Carrinho ; Galvão Bueno, Alexandre ; Morais, Carlos-Floriano de ; Nagai, Hildebrando-Massahiro ; Kunz, Reno ; Lopes, Márcio Ajudarte. Histopathological grading systems analysis of oral squamous cell carcinomas of young patients. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2016, Vol. 21, No. 3: 285-	es
dc.identifier.uri	http://hdl.handle.net/10550/54771
dc.description.abstract	Background: To analyze the clinicopathological profile of young patients (≤ 40 years) with oral SCC and correlate with a control group (≥ 50 years) by means of histopathological grading systems. Material and Methods: 14 young patients and 14 control patients were selected with similar clinical stage and tumor location. Demographic and clinical data were obtained from patient records and histological sections were evaluated according to four histopathological grading systems. Associations between categories of demographic and clinical data were performed through Chi-square test and Exact Fisher test. The survival analyzes were performed according to the Kaplan-Meier method. Results: The comparison between groups showed a greater association of treatment modalities in younger patients ( p =0.022), they had a higher incidence of local recurrence and regional metastasis ( p =0.018) and lower disease- free survival in 5 years ( p =0.069). There was no difference in 5-year overall survival among the studied groups. There was no difference in histological grading between studied groups according to the four used systems. Conclusions: This study showed that, despite tumors had similar histological grade and more therapeutic modalities were used in the young group, tumors in young patients had a higher incidence of recurrence/metastasis, showing tendency to a more aggressive behavior.	en_US
dc.relation		es
dc.subject	Odontología	es
dc.subject	Ciencias de la salud	es
dc.title	Histopathological grading systems analysis of oral squamous cell carcinomas of young patients	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.type.hasVersion	VoR	es_ES