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Serum zinc levels in 368 patients with oral mucosal diseases: a preliminary study

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Serum zinc levels in 368 patients with oral mucosal diseases: a preliminary study

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dc.contributor.author Bao, Zhe-Xuan es
dc.contributor.author Yang, Xiao-Wen es
dc.contributor.author Shi, Jing es
dc.contributor.author Liu, Li-Xin es
dc.date.accessioned 2016-07-26T11:58:25Z
dc.date.available 2016-07-26T11:58:25Z
dc.date.issued 2016 es
dc.identifier.citation Bao, Zhe-Xuan ; Yang, Xiao-Wen ; Shi, Jing ; Liu, Li-Xin. Serum zinc levels in 368 patients with oral mucosal diseases: a preliminary study. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2016, Vol. 21, No. 3: 335- es
dc.identifier.uri http://hdl.handle.net/10550/54777
dc.description.abstract Background: The aim of this study was to assess the serum zinc levels in patients with common oral mucosal diseases by comparing these to healthy controls. Material and Methods: A total of 368 patients, which consisted of 156 recurrent aphthous stomatitis (RAS) patients, 57 oral lichen planus (OLP) patients, 55 burning mouth syndrome (BMS) patients, 54 atrophic glossitis (AG) patients, 46 xerostomia patients, and 115 sex-and age-matched healthy control subjects were enrolled in this study. Serum zinc levels were measured in all participants. Statistical analysis was performed using a one-way ANOVA, t-test, and Chi-square test. Results: The mean serum zinc level in the healthy control group was significantly higher than the levels of all other groups ( p < 0.001). No individual in the healthy control group had a serum zinc level less than the minimum normal value. However, up to 24.7% (13/54) of patients with AG presented with zinc deficiency, while 21.2% (33/156) of patients with RAS, 16.4% (9/55) of patients with BMS, 15.2% (7/46) of patients with xerostomia, and 14.0% (8/57) of patients with OLP were zinc deficient. Altogether, the zinc deficiency rate was 19.02% (70/368) in the oral mucosal diseases (OMD) group (all patients with OMD). The difference between the OMD and healthy control group was significant ( p < 0.001). Gender differences in serum zinc levels were also present, although not statistically significant. Conclusions: Zinc deficiency may be involved in the pathogenesis of common oral mucosal diseases. Zinc supplementation may be a useful treatment for oral mucosal diseases, but this requires further investigation; the optimal serum level of zinc, for the prevention and treatment of oral mucosal diseases, remains to be determined. en_US
dc.relation es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Serum zinc levels in 368 patients with oral mucosal diseases: a preliminary study es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.type.hasVersion VoR es_ES

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