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Association of Toll-like receptors 2, 3, and 4 genes polymorphisms with periapical pathosis risk

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Association of Toll-like receptors 2, 3, and 4 genes polymorphisms with periapical pathosis risk

dc.contributor.author	Özan, Ülkü	es
dc.contributor.author	Ocak, Zeynep	es
dc.contributor.author	Özan, Fatih	es
dc.contributor.author	Oktay, Elif-Aybala	es
dc.contributor.author	Toptaş, Orçun	es
dc.contributor.author	Sahman, Halil	es
dc.contributor.author	Yikilgan, İhsan	es
dc.contributor.author	Orucoglu, Hasan	es
dc.contributor.author	Er, Kürşat	es
dc.date.accessioned	2016-07-26T11:59:59Z
dc.date.available	2016-07-26T11:59:59Z
dc.date.issued	2016	es
dc.identifier.citation	Özan, Ülkü ; Ocak, Zeynep ; Özan, Fatih ; Oktay, Elif-Aybala ; Toptaş, Orçun ; Sahman, Halil ; Yikilgan, İhsan ; Orucoglu, Hasan ; Er, Kürşat. Association of Toll-like receptors 2, 3, and 4 genes polymorphisms with periapical pathosis risk. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2016, Vol. 21, No. 4: 408-	es
dc.identifier.uri	http://hdl.handle.net/10550/54787
dc.description.abstract	Background: The aim of this study was to investigate the role of gene variations of Toll-like receptors (TLR) 2, 3, and 4 on genetic susceptibility to periapical pathosis. Material and Methods: One hundred patients were included in the study and divided into two groups as follows; Control Group (n=50) that have root canal treatment and no periapical lesion, Patient Group (n=50) that have root canal treatment and periapical lesion. TLR2 Arg753Gln, TLR3 (c.1377C/T) and TLR4 Asp299Gly and Thr399Ile polymorphisms were genotyped by using PCR-RFLP. Genotypical analysis of control and patient groups were investigated to disclose whether there is any association between periapical lesions and gene variations. Results: There are no significant statistical differences between control and patient groups according to TLR 2 and 4 gene sequence. On the contrary, CC allele detected 74% for TLR 3 in patient group, and this difference was found to be statistically significant ( p < 0.005). Conclusions: According to these results, it can be suggested that patients with Toll-like receptor 3 gene polymorphisms could be susceptible to periapical pathosis.	en_US
dc.relation		es
dc.subject	Odontología	es
dc.subject	Ciencias de la salud	es
dc.title	Association of Toll-like receptors 2, 3, and 4 genes polymorphisms with periapical pathosis risk	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.type.hasVersion	VoR	es_ES