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Plant virus cell-to-cell movement is not dependent on the transmembrane disposition of its movement protein

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Plant virus cell-to-cell movement is not dependent on the transmembrane disposition of its movement protein

dc.contributor.author	Martínez Gil, Luis
dc.contributor.author	Sánchez Navarro, Jesús A.
dc.contributor.author	Cruz, Antonio
dc.contributor.author	Pallás Benet, Vicente
dc.contributor.author	Pérez Gil, Jesús
dc.contributor.author	Mingarro Muñoz, Ismael
dc.date.accessioned	2016-09-06T16:20:47Z
dc.date.available	2016-09-06T16:20:47Z
dc.date.issued	2009
dc.identifier.citation	Martínez Gil, Luis Sánchez Navarro, Jesús A. Cruz, Antonio Pallás Benet, Vicente Pérez Gil, Jesús Mingarro Muñoz, Ismael 2009 Plant virus cell-to-cell movement is not dependent on the transmembrane disposition of its movement protein Journal of Virology 83 11 5535 5543
dc.identifier.uri	http://hdl.handle.net/10550/54926
dc.description.abstract	The cell-to-cell transport of plant viruses depends on one or more virus-encoded movement proteins (MPs). Some MPs are integral membrane proteins that interact with the membrane of the endoplasmic reticulum, but a detailed understanding of the interaction between MPs and biological membranes has been lacking. The cell-to-cell movement of the Prunus necrotic ringspot virus (PNRSV) is facilitated by a single MP of the 30K superfamily. Here, using a myriad of biochemical and biophysical approaches, we show that the PNRSV MP contains only one hydrophobic region (HR) that interacts with the membrane interface, as opposed to being a transmembrane protein. We also show that a proline residue located in the middle of the HR constrains the structural conformation of this region at the membrane interface, and its replacement precludes virus movement.
dc.language.iso	eng
dc.relation.ispartof	Journal of Virology, 2009, vol. 83, num. 11, p. 5535-5543
dc.subject	Virus
dc.subject	Proteïnes de membrana
dc.subject	Microbiologia
dc.title	Plant virus cell-to-cell movement is not dependent on the transmembrane disposition of its movement protein
dc.type	journal article	es_ES
dc.date.updated	2016-09-06T16:20:47Z
dc.identifier.doi	10.1128/JVI.00393-09
dc.identifier.idgrec	053688
dc.rights.accessRights	open access	es_ES