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Double-spanning Plant Viral Movement Protein Integration into the Endoplasmic Reticulum Membrane Is Signal Recognition Particle-dependent, Translocon-mediated, and Concerted

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Double-spanning Plant Viral Movement Protein Integration into the Endoplasmic Reticulum Membrane Is Signal Recognition Particle-dependent, Translocon-mediated, and Concerted

dc.contributor.author	Saurí Peris, Ana
dc.contributor.author	Saksena, Suraj
dc.contributor.author	Salgado Benito, Jesús
dc.contributor.author	Johnson, Arthur E.
dc.contributor.author	Mingarro Muñoz, Ismael
dc.date.accessioned	2016-09-07T18:10:38Z
dc.date.available	2016-09-07T18:10:38Z
dc.date.issued	2005
dc.identifier.citation	Saurí Peris, Ana Saksena, Suraj Salgado Benito, Jesús Johnson, Arthur E. Mingarro Muñoz, Ismael 2005 Double-spanning Plant Viral Movement Protein Integration into the Endoplasmic Reticulum Membrane Is Signal Recognition Particle-dependent, Translocon-mediated, and Concerted Journal of Biological Chemistry 280 27 25907 25912
dc.identifier.uri	http://hdl.handle.net/10550/54942
dc.description.abstract	The current model for cell-to-cell movement of plant viruses holds that transport requires virus-encoded movement proteins that intimately associate with endoplasmic reticulum membranes. We have examined the early stages of the integration into endoplasmic reticulum membranes of a double-spanning viral movement protein using photocross-linking. We have discovered that this process is cotranslational and proceeds in a signal recognition particle-dependent manner. In addition, nascent chain photocross-linking to Sec61alpha and translocating chain-associated membrane protein reveal that viral membrane protein insertion takes place via the translocon, as with most eukaryotic membrane proteins, but that the two transmembrane segments of the viral protein leave the translocon and enter the lipid bilayer together.
dc.language.iso	eng
dc.relation.ispartof	Journal of Biological Chemistry, 2005, vol. 280, num. 27, p. 25907-25912
dc.subject	Bioquímica
dc.subject	Membranes (Biologia)
dc.title	Double-spanning Plant Viral Movement Protein Integration into the Endoplasmic Reticulum Membrane Is Signal Recognition Particle-dependent, Translocon-mediated, and Concerted
dc.type	journal article	es_ES
dc.date.updated	2016-09-07T18:10:38Z
dc.identifier.doi	10.1074/jbc.M412476200
dc.identifier.idgrec	020388
dc.rights.accessRights	open access	es_ES