Vision-based sensing algorithms are computationally-demanding tasks due to the large amount of data acquired and processed. Visual sensors deliver much information, even if data are redundant, and do not give any additional information. A Selective Change Driven (SCD) sensing system is based on a sensor that delivers, ordered by the magnitude of its change, only those pixels that have changed most since the last read-out. This allows the information stream to be adjusted to the computation capabilities. Following this strategy, a new SCD processing architecture for high-speed motion analysis, based on processing pixels instead of full frames, has been developed and implemented into a Field Programmable Gate-Array (FPGA). The programmable device controls the data stream, delivering a new object distance calculation for every new pixel. The acquisition, processing and delivery of a new object distance takes just 1.7 μ s. Obtaining a similar result using a conventional frame-based camera would require a device working at roughly 500 Kfps, which is far from being practical or even feasible. This system, built with the recently-developed 64 × 64 CMOS SCD sensor, shows the potential of the SCD approach when combined with a hardware processing system.