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Synthetic Pulmonary Surfactant Preparations: New developments and future trends

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Synthetic Pulmonary Surfactant Preparations: New developments and future trends

dc.contributor.author	Mingarro Muñoz, Ismael
dc.contributor.author	Lukovic, Dunja
dc.contributor.author	Vilar, Marçal
dc.contributor.author	Pérez Gil, Jesús
dc.date.accessioned	2016-12-01T16:27:51Z
dc.date.available	2016-12-01T16:27:51Z
dc.date.issued	2008
dc.identifier.citation	Mingarro Muñoz, Ismael Lukovic, Dunja Vilar, Marçal Pérez Gil, Jesús 2008 Synthetic Pulmonary Surfactant Preparations: New developments and future trends Current Medicinal Chemistry 15 4 393 403
dc.identifier.uri	http://hdl.handle.net/10550/56222
dc.description.abstract	Pulmonary surfactant is a lipid-protein complex that coats the interior of the alveoli and enables the lungs to function properly. Upon its synthesis, lung surfactant adsorbs at the interface between the air and the hypophase, a capillary aqueous layer covering the alveoli. By lowering and modulating surface tension during breathing, lung surfactant reduces respiratory work of expansion, and stabilises alveoli against collapse during expiration. Pulmonary surfactant deficiency, or dysfunction, contributes to several respiratory pathologies, such as infant respiratory distress syndrome (IRDS) in premature neonates, and acute respiratory distress syndrome (ARDS) in children and adults. The main clinical exogenous surfactants currently in use to treat some of these pathologies are essentially organic extracts obtained from animal lungs. Although very efficient, natural surfactants bear serious defects: i) they could vary in composition from batch to batch; ii) their production involves relatively high costs, and sources are limited; and iii) they carry a potential risk of transmission of animal infectious agents and the possibility of immunological reaction. All these caveats justify the necessity for a highly controlled synthetic material. In the present review the efforts aimed at new surfactant development, including the modification of existing exogenous surfactants by adding molecules that can enhance their activity, and the progress achieved in the production of completely new preparations, are discussed.
dc.language.iso	eng
dc.relation.ispartof	Current Medicinal Chemistry, 2008, vol. 15, num. 4, p. 393-403
dc.subject	Pulmons Malalties
dc.subject	Proteïnes
dc.title	Synthetic Pulmonary Surfactant Preparations: New developments and future trends
dc.type	journal article	es_ES
dc.date.updated	2016-12-01T16:27:52Z
dc.identifier.doi	10.2174/092986708783497364
dc.identifier.idgrec	041303
dc.rights.accessRights	open access	es_ES