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Afferent and Efferent connections of the cortex-amygdala transition zone in mice

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Afferent and Efferent connections of the cortex-amygdala transition zone in mice

dc.contributor.author	Cádiz Moretti, Bernardita
dc.contributor.author	Abellán-Álvaro, María
dc.contributor.author	Pardo Bellver, Cecilia
dc.contributor.author	Martínez-García, Fernando
dc.contributor.author	Lanuza Navarro, Enrique
dc.date.accessioned	2017-02-14T15:27:11Z
dc.date.available	2017-02-14T15:27:11Z
dc.date.issued	2016
dc.identifier.citation	Cádiz Moretti, Bernardita Abellán-Álvaro, María Pardo Bellver, Cecilia Martínez-García, Fernando Lanuza Navarro, Enrique 2016 Afferent and Efferent connections of the cortex-amygdala transition zone in mice Frontiers In Neuroanatomy 10 125
dc.identifier.uri	http://hdl.handle.net/10550/57160
dc.description.abstract	The transitional zone between the ventral part of the piriform cortex and the anterior cortical nucleus of the amygdala, named the cortex-amygdala transition zone (CxA), shows two differential features that allow its identification as a particular structure. First, it receives dense cholinergic and dopaminergic innervations as compared to the adjacent piriform cortex and amygdala, and second, it receives projections from the main and accessory olfactory bulbs. In this work we have studied the pattern of afferent and efferent projections of the CxA, which are mainly unknown, by using the retrograde tracer Fluorogold and the anterograde tracer biotinylated dextranamine. The results show that the CxA receives a relatively restricted set of intratelencephalic connections, originated mainly by the olfactory system and basal forebrain, with minor afferents from the amygdala. The only relevant extratelencephalic afference originates in the ventral tegmental area (VTA). The efferent projections of the CxA reciprocate the inputs from the piriform cortex and olfactory amygdala. In addition, the CxA projects densely to the basolateral amygdaloid nucleus and the olfactory tubercle. The extratelencephalic projections of the CxA are very scarce, and target mainly hypothalamic structures. The pattern of connections of the CxA suggests that it is indeed a transitional area between the piriform cortex and the cortical amygdala. Double labeling with choline acetyltransferase indicates that the afferent projection from the basal forebrain is the origin of its distinctive cholinergic innervation, and double labeling with dopamine transporter shows that the projection from the VTA is the source of dopaminergic innervation. These connectivity and neurochemical features, together with the fact that it receives vomeronasal in addition to olfactory information, suggest that the CxA may be involved in processing olfactory information endowed with relevant biological meaning, such as odors related to reproductive or defensive behaviors.
dc.language.iso	eng
dc.relation.ispartof	Frontiers In Neuroanatomy, 2016, vol. 10, num. 125
dc.subject	Neuroanatomia
dc.subject	Sistema nerviós central Malalties
dc.subject	Olfacte
dc.title	Afferent and Efferent connections of the cortex-amygdala transition zone in mice
dc.type	journal article	es_ES
dc.date.updated	2017-02-14T15:27:11Z
dc.identifier.doi	10.3389/fnana.2016.00125
dc.identifier.idgrec	116194
dc.rights.accessRights	open access	es_ES