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Transmission dynamics of HIV-1 subtype B in the Basque Country, Spain

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Transmission dynamics of HIV-1 subtype B in the Basque Country, Spain

dc.contributor.author	Patiño-Galindo, Juan Ángel
dc.contributor.author	Thomson, Miguel M.
dc.contributor.author	Pérez-Álvarez, Lucía
dc.contributor.author	Delgado, Elena
dc.contributor.author	Cuevas, María Teresa
dc.contributor.author	Fernández-García, Aurora
dc.contributor.author	Nájera Morrondo, Rafael
dc.contributor.author	Iribarren, José A.
dc.contributor.author	Cilla, Gustavo
dc.contributor.author	López-Soria, Leyre
dc.contributor.author	Lezaun, María J.
dc.contributor.author	Cisterna, Ramón
dc.contributor.author	González Candelas, Fernando
dc.date.accessioned	2017-05-08T14:17:12Z
dc.date.available	2017-05-08T14:17:12Z
dc.date.issued	2016
dc.identifier.citation	Patiño-Galindo, Juan Ángel Thomson, Miguel M. Pérez-Álvarez, Lucía Delgado, Elena Cuevas, María Teresa Fernández-García, Aurora Nájera Morrondo, Rafael Iribarren, José A. Cilla, Gustavo López-Soria, Leyre Lezaun, María J. Cisterna, Ramón González Candelas, Fernando 2016 Transmission dynamics of HIV-1 subtype B in the Basque Country, Spain Infection Genetics And Evolution 40 91 97
dc.identifier.uri	http://hdl.handle.net/10550/58396
dc.description.abstract	This work was aimed to study the HIV-1 subtype B epidemics in the Basque Country, Spain. 1727 HIV-1 subtype B sequences comprising protease and reverse transcriptase (PR/RT) coding regions, sampled between 2001 and 2008, were analyzed. 156 transmission clusters were detected by means of phylogenetic analyses. Most of them comprised less than 4 individuals and, in total, they included 441 patients. Six clusters comprised 10 or more patients and were further analyzed in order to study their origin and diversification. Four clusters included men who had unprotected homosexual sex (MSM), one group was formed by intravenous drug users (IDUs), and another included both IDUs and people infected through unprotected heterosexual sex (HTs). Most of these clusters originated from the mid-1980s to the mid-1990s. Only one cluster, formed by MSM, originated after 2000. The time between infections was significantly lower in MSM groups than in those containing IDUs (P-value < 0.0001). Nucleoside RT and non-nucleoside RT inhibitor (NRTI and NNRTI)-resistance mutations to antiretroviral treatment were found in these six clusters except the most recent MSM group, but only the IDU clusters presented protease inhibitor (PI)-resistance mutations. The most prevalent mutations for each inhibitor class were PI L90M, NRTI T215D/Y/F, and NNRTI K103N, which were also among the most prevalent resistant variants in the whole dataset. In conclusion, while most infections occur as isolated introductions into the population, the number of infections found to be epidemiologically related within the Basque Country is significant. Public health control measures should be reinforced to prevent the further expansion of transmission clusters and resistant mutations occurring within them.
dc.language.iso	eng
dc.relation.ispartof	Infection Genetics And Evolution, 2016, vol. 40, p. 91-97
dc.subject	Virus
dc.subject	Infecció
dc.title	Transmission dynamics of HIV-1 subtype B in the Basque Country, Spain
dc.type	journal article	es_ES
dc.date.updated	2017-05-08T14:17:13Z
dc.identifier.doi	10.1016/j.meegid.2016.02.028
dc.identifier.idgrec	110286
dc.rights.accessRights	open access	es_ES