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Atypical methotrexate ulcerative stomatitis with features of lymphoproliferative like disorder: report of a rare ciprofloxacin-induced case and review of the literature

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Atypical methotrexate ulcerative stomatitis with features of lymphoproliferative like disorder: report of a rare ciprofloxacin-induced case and review of the literature

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dc.contributor.author Katsoulas, Nikolaos es
dc.contributor.author Chrysomali, Evanthia es
dc.contributor.author Piperi, Evangelia es
dc.contributor.author Levidou, Georgia es
dc.contributor.author Sklavounou-Andrikopoulou, Alexandra es
dc.date.accessioned 2017-05-10T07:27:50Z
dc.date.available 2017-05-10T07:27:50Z
dc.date.issued 2016 es
dc.identifier.citation Katsoulas, Nikolaos ; Chrysomali, Evanthia ; Piperi, Evangelia ; Levidou, Georgia ; Sklavounou-Andrikopoulou, Alexandra. Atypical methotrexate ulcerative stomatitis with features of lymphoproliferative like disorder: report of a rare ciprofloxacin-induced case and review of the literature. En: Journal of Clinical and Experimental Dentistry. 2016. Vol. 8, no. 5: 629 es
dc.identifier.uri http://hdl.handle.net/10550/58433
dc.description.abstract Methotrexate (MTX) is an established immunomodulating agent used in low doses (LDMTX) to treat several autoimmune diseases. Ulcerative stomatitis (US) may be observed as a long-term LDMTX adverse effect showing a wide histopathologic spectrum. A 73-year old female presented with painful oral ulcers of 5 days duration. The patient had been under treatment for rheumatoid arthritis with LDMTX, while one week before presentation she was prescribed ciprofloxacin for a urinary infection. Histopathologic examination of a lingual ulcer revealed a polymorphous lymphohistiocytic proliferation with scattered binucleated atypical lymphocytes. Immunohistochemically, most cells were of T-cell lineage while the EBER test was negative and a diagnosis of MTX-induced reactive ulceration was rendered. MTX cessation resulted in complete resolution of the ulcers with no recurrences reported so far. The clinical and histopathologic features of MTX-induced oral ulcers are not always diagnostic and a detailed history and an extensive clinicopathologic investigation may be needed to exclude a lymphoproliferative disorder. en_US
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Atypical methotrexate ulcerative stomatitis with features of lymphoproliferative like disorder: report of a rare ciprofloxacin-induced case and review of the literature es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÃ DICAS es
dc.type.hasVersion VoR es_ES

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