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Diabetes screening by telecentric digital holographic microscopy

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Diabetes screening by telecentric digital holographic microscopy

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dc.contributor.author	Doblas Expósito, Ana Isabel
dc.contributor.author	Roche, Enrique
dc.contributor.author	Ampudia Blasco, Francisco Javier
dc.contributor.author	Martínez Corral, Manuel
dc.contributor.author	Saavedra Tortosa, Genaro
dc.contributor.author	García Sucerquia, Jorge Iván
dc.date.accessioned	2017-05-23T15:11:45Z
dc.date.available	2017-05-23T15:11:45Z
dc.date.issued	2016
dc.identifier.citation	Doblas Expósito, Ana Isabel Roche, Enrique Ampudia Blasco, Francisco Javier Martínez Corral, Manuel Saavedra Tortosa, Genaro García Sucerquia, Jorge Iván 2016 Diabetes screening by telecentric digital holographic microscopy Journal of Microscopy 261 3 285 290
dc.identifier.uri	http://hdl.handle.net/10550/58604
dc.description.abstract	Diabetes is currently the world's fastest growing chronic disease and it is caused by deficient production of insulin by the endocrine pancreas or by abnormal insulin action in peripheral tissues. This results in persistent hyperglycaemia that over time may produce chronic diabetic complications. Determination of glycated haemoglobin level is currently the gold standard method to evaluate and control sustained hyperglycaemia in diabetic people. This measurement is currently made by high-performance liquid chromatography, which is a complex chemical process that requires the extraction of blood from the antecubital vein. To reduce the complexity of that measurement, we propose a fully-optical technique that is based in the fact that there are changes in the optical properties of erythrocytes due to the presence of glucose-derived adducts in the haemoglobin molecule. To evaluate these changes, we propose to perform quantitative phase maps of erythrocytes by using telecentric digital holographic microscopy. Our experiments show that telecentric digital holographic microscopy allows detecting, almost in real time and from a single drop of blood, significant differences between erythrocytes of diabetic patients and healthy patients. Besides, our phase measurements are well correlated with the values of glycated haemoglobin and the blood glucose values.
dc.language.iso	eng
dc.relation.ispartof	Journal of Microscopy, 2016, vol. 261, num. 3, p. 285-290
dc.subject	Diabetis
dc.subject	Microscòpia
dc.title	Diabetes screening by telecentric digital holographic microscopy
dc.type	journal article	es_ES
dc.date.updated	2017-05-23T15:11:47Z
dc.identifier.doi	10.1111/jmi.12331
dc.identifier.idgrec	110738
dc.rights.accessRights	open access	es_ES