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An in vitro analysis model for investigating the staining effect of various chlorhexidine-based mouthwashes

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An in vitro analysis model for investigating the staining effect of various chlorhexidine-based mouthwashes

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dc.contributor.author Kouadio, Alain Ayepa es
dc.contributor.author Struillou, Xavier es
dc.contributor.author Bories, Céline es
dc.contributor.author Bouler, Jean Michel es
dc.contributor.author Badran, Zahi es
dc.contributor.author Soueidan, Assem es
dc.date.accessioned 2017-07-18T11:52:47Z
dc.date.available 2017-07-18T11:52:47Z
dc.date.issued 2017 es
dc.identifier.citation Kouadio, Alain Ayepa ; Struillou, Xavier ; Bories, Céline ; Bouler, Jean Michel ; Badran, Zahi ; Soueidan, Assem. An in vitro analysis model for investigating the staining effect of various chlorhexidine-based mouthwashes. En: Journal of Clinical and Experimental Dentistry, 9 3 2017: 410-416 es
dc.identifier.uri http://hdl.handle.net/10550/59590
dc.description.abstract There are different mouthwashes containing chlorhexidine in different concentrations, as well as various excipients. Chlorhexidine induce stains or discoloration in teeth and mucous membranes. The aim of this work was to design a model to reproduce in vitro staining associated with the use of different mouthwashes containing chlorhexidine. We used as substrates of natural teeth and elephant ivory slices. Different incubation baths were conducted over 21 days in culture dishes at 37°C. At the beginning of experiment before incubation (D0) and after 21 days (D21) of incubation with different mouthwashes, pictures of substrates were taken in a standardized manner and an image analysis software was used to analyse and quantify the staining under the various conditions by using the 3 main colours (Red, Green, Blue, RGB). The results of this work demonstrate a very good reproducibility of the protocol, and secondly, a different expression statistically significant of the primary blue colour. We suggest that for a given concentration of chlorhexidine, the staining effects may vary depending on the excipients used. This replicable model, easy to implement over a relatively short duration, can be used for evaluation of existing mouthwashes, and to test the excipients anti discoloration proposed by manufacturers. es
dc.title An in vitro analysis model for investigating the staining effect of various chlorhexidine-based mouthwashes es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/jced.53375 es
dc.type.hasVersion VoR es_ES

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