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Lubricin in synovial fluid of mild and severe temporomandibular joint internal derangements

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Lubricin in synovial fluid of mild and severe temporomandibular joint internal derangements

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dc.contributor.author Leonardi, Rosalia es
dc.contributor.author Perrotta, Rosario E. es
dc.contributor.author Almeida, Luis Eduardo es
dc.contributor.author Loreto, Carla es
dc.contributor.author Musumeci, Giuseppe es
dc.date.accessioned 2017-07-21T10:17:19Z
dc.date.available 2017-07-21T10:17:19Z
dc.date.issued 2016 es
dc.identifier.citation Leonardi, Rosalia ; Perrotta, Rosario E. ; Almeida, Luis Eduardo ; Loreto, Carla ; Musumeci, Giuseppe. Lubricin in synovial fluid of mild and severe temporomandibular joint internal derangements. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 21 6 2016: 12- es
dc.identifier.uri http://hdl.handle.net/10550/59790
dc.description.abstract To understand the molecular basis of temporomandibular joint (TMJ) pathologies, we aimed to investigate the lubricin levels in the TMJ synovial fluid (SF) of patients with mild to severe internal derangements (IDs). A total, 34 joints were the study group. Only patients, with a Wilkes stage of III, IV and V were included, in this sample. Control group consisted of SF from eight joints, from patients undergoing to orthognatic surgery. Concentrations of lubricin in the SF from both samples were measured using ELISA system. The mean lubricin concentration was 7.029 ± 0.21 µg/mL in stage III patients; 5.64 ± 0.10 µg/mL in stage IV patients, and 4.78 ± 0.11 µg/mL in stage V patients. The lubricin levels from stage IV and stage V patients differed significantly (P ? 0.001) from those of control subjects. Lubricin levels were inversely correlated with age and to VAS score. The results of this cross-sectional study highlight the relationship between disease severity and the levels of lubricin in TMJ SF. Our findings suggest that novel biotherapeutic approaches, including the administration of recombinant lubricin in the joint cavity, for the treatment of TMJ diseases can be developed. es
dc.title Lubricin in synovial fluid of mild and severe temporomandibular joint internal derangements es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.21145 es
dc.type.hasVersion VoR es_ES

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