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Efficacy of naproxen with or without esomeprazole for pain and inflammation in patients after bilateral third molar extractions : a double blinded crossover study

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Efficacy of naproxen with or without esomeprazole for pain and inflammation in patients after bilateral third molar extractions : a double blinded crossover study

dc.contributor.author	Weckwerth, Giovana M.	es
dc.contributor.author	Simoneti, Luis F.	es
dc.contributor.author	Zupelari Gonçalves, Paulo	es
dc.contributor.author	Calvo, Adriana M.	es
dc.contributor.author	Brozoski, Daniel T.	es
dc.contributor.author	Dionísio, Thiago José	es
dc.contributor.author	Torres, Elza A.	es
dc.contributor.author	Lauris, José Roberto Pereira	es
dc.contributor.author	Faria, Flávio Augusto C.	es
dc.contributor.author	Santos, Carlos F.	es
dc.date.accessioned	2017-07-21T11:50:40Z
dc.date.available	2017-07-21T11:50:40Z
dc.date.issued	2017	es
dc.identifier.citation	Weckwerth, Giovana M. ; Simoneti, Luis F. ; Zupelari Gonçalves, Paulo ; Calvo, Adriana M. ; Brozoski, Daniel T. ; Dionísio, Thiago José ; Torres, Elza A. ; Lauris, José Roberto Pereira ; Faria, Flávio Augusto C. ; Santos, Carlos F.. Efficacy of naproxen with or without esomeprazole for pain and inflammation in patients after bilateral third molar extractions : a double blinded crossover study. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 22 1 2017: 14-	es
dc.identifier.uri	http://hdl.handle.net/10550/59796
dc.description.abstract	Using a double-blinded randomized crossover design, this study aimed to evaluate acute postoperative pain management, swelling and trismus in 46 volunteers undergoing extractions of the two lower third molars, in similar positions, at two different appointments who consumed a tablet of either NE (naproxen 500 mg + esomepraz ole 20 mg) or only naproxen (500 mg) every 12 hours for 4 days. Parameters were analyzed: self-reported pain intensity using a visual analog scale (VAS) pre- and postoperative mouth opening; incidence, type and severity of adverse reactions; total quantity consumed of rescue medication; and pre- and postoperative swelling. Female volunteers reported significantly more postoperative pain at 1, 1.5, 2, 3 and 4hrs after surgery while also taking their first rescue medication at a time significantly earlier when consuming NE when compared to naproxen (3.7hrs and 6.7hrs). Conversely, no differences were found between each drug group in males. In conclusion, throughout the entire study, pain was mild after using either drug in both men and women with pain scores on average well below 40mm (VAS), although in women naproxen improved acute postoperative pain management when compared to NE.	es
dc.title	Efficacy of naproxen with or without esomeprazole for pain and inflammation in patients after bilateral third molar extractions : a double blinded crossover study	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.21514	es
dc.type.hasVersion	VoR	es_ES