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Could formaldehyde induce mutagenic and cytotoxic effects in buccal epithelial cells during anatomy classes?

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Could formaldehyde induce mutagenic and cytotoxic effects in buccal epithelial cells during anatomy classes?

dc.contributor.author	Lorenzoni, Diego Coelho	es
dc.contributor.author	Pinheiro, Leon Penido	es
dc.contributor.author	Nascimento, Haniel Serpa	es
dc.contributor.author	Menegardo, Cristiani Sartorio	es
dc.contributor.author	Silva, Ronara Gerhardt	es
dc.contributor.author	Bautz, Willian Grassi	es
dc.contributor.author	Henriques, José Fernando	es
dc.contributor.author	Almeida Coburn, Karla Loureiro	es
dc.contributor.author	da Gama de Souza, Letícia Nogueira	es
dc.date.accessioned	2017-07-21T11:50:41Z
dc.date.available	2017-07-21T11:50:41Z
dc.date.issued	2017	es
dc.identifier.citation	Lorenzoni, Diego Coelho ; Pinheiro, Leon Penido ; Nascimento, Haniel Serpa ; Menegardo, Cristiani Sartorio ; Silva, Ronara Gerhardt ; Bautz, Willian Grassi ; Henriques, José Fernando ; Almeida Coburn, Karla Loureiro ; da Gama de Souza, Letícia Nogueira. Could formaldehyde induce mutagenic and cytotoxic effects in buccal epithelial cells during anatomy classes?. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 22 1 2017: 7-	es
dc.identifier.uri	http://hdl.handle.net/10550/59803
dc.description.abstract	Due to increased formaldehyde exposure, carcinogenic to humans, several researches have been studying the potential toxicity and the safe levels for human beings. The aim of this study was to investigate mutagenicity and cytotoxicity in buccal epithelial exfoliated cells (BEC) of students subjected to formaldehyde (FA) during anatomy classes. BEC were collected periodically from 17 volunteers of undergraduate programs, who had participated in practical anatomy classes, before and after FA exposure. Cells were stained according to Feulgen method and then micronucleus test was applied. A total of 1,500 cells were assessed per individual in this study for the micronucleus frequency and other parameters of cytotoxicity. There was statistically significant increase in number of micronucleated BEC after FA exposure (after 1 month p=.034 and after 3.5 months p=.017). However, FA exposure caused no significant increase in other nuclear alterations closely related to cytotoxicity (p?.05). FA induced mutagenicity during anatomy classes. Cell death increased, but it was not statistically significant. Efforts have to be made to improve air quality and reduce exposures during anatomy classes.	es
dc.title	Could formaldehyde induce mutagenic and cytotoxic effects in buccal epithelial cells during anatomy classes?	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.21492	es
dc.type.hasVersion	VoR	es_ES