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Influence of bethanechol on salivary parameters in irradiated patients

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Influence of bethanechol on salivary parameters in irradiated patients

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dc.contributor.author Cotomacio, Claudia es
dc.contributor.author Campos, Luana es
dc.contributor.author Simões, Alyne es
dc.contributor.author Jaguar, Graziella Chagas es
dc.contributor.author Crosato, Edgard-Michel es
dc.contributor.author Alves, Fabio A. es
dc.date.accessioned 2017-07-21T11:50:41Z
dc.date.available 2017-07-21T11:50:41Z
dc.date.issued 2017 es
dc.identifier.citation Cotomacio, Claudia ; Campos, Luana ; Simões, Alyne ; Jaguar, Graziella Chagas ; Crosato, Edgard-Michel ; Alves, Fabio A.. Influence of bethanechol on salivary parameters in irradiated patients. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 22 1 2017: 1- es
dc.identifier.uri http://hdl.handle.net/10550/59807
dc.description.abstract Some studies have shown evidence that the prophylactic use of bethanechol chloride (BC) may be useful in preventing the incidence and/or severity of xerostomia (XT). However, the indication of BC in irradiated patients with XT needs to be better characterized. The study aimed to evaluate the influence of BC on XT, salivary flow rate, and salivary composition in patients previously submitted to head and neck radiotherapy. Forty five irradiated patients complaining of XT used 50 mg/day of BC for 3 months, and the salivary parameters were evaluated in 4 Phases (Before BC therapy, after one month of BC, 2 months of BC, and 3 months of BC). Biochemical analysis included buffering capacity; pH; total protein concentration (TP); amylase concentration (AM); catalase (CAT) and peroxidase (PX) activities. In addition, unstimulated and stimulated salivary flow rates were determined and XT was classified. According to the XT grading system used, patients showed improvement in XT between Phase 1, and Phases 2, 3 and 4. In addition, some changes were observed in TP concentration (decreased); AM concentration (increased); and PX and CAT activities (decreased and increased, respectively) after Phase 2, for stimulated saliva collection (p<0.05). Our results suggested that when BC was used to treat salivary gland dysfunction induced by head and neck radiotherapy, improvement in XT symptoms, and some changes in saliva composition were shown. es
dc.title Influence of bethanechol on salivary parameters in irradiated patients es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.21395 es
dc.type.hasVersion VoR es_ES

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