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Dental extraction following zoledronate, induces osteonecrosis in rat´s jaw

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Dental extraction following zoledronate, induces osteonecrosis in rat´s jaw

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dc.contributor.author Vidal Gutiérrez, Ximena es
dc.contributor.author Gómez Clavel, José Francisco es
dc.contributor.author Gaitán Cepeda, Luis Alberto es
dc.date.accessioned 2017-07-24T07:14:29Z
dc.date.available 2017-07-24T07:14:29Z
dc.date.issued 2017 es
dc.identifier.citation Vidal Gutiérrez, Ximena ; Gómez Clavel, José Francisco ; Gaitán Cepeda, Luis Alberto. Dental extraction following zoledronate, induces osteonecrosis in rat´s jaw. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 22 2 2017: 6- es
dc.identifier.uri http://hdl.handle.net/10550/59822
dc.description.abstract Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ) is clinically characterized by the presence of exposed bone in the oral cavity that persists for more than eight weeks. Previous attempts to establish an animal model have not sufficiently considered disease features. Our aim was to establish an inexpensive and replicable animal model that develops BRONJ in a short time. Thirty-two male Wistar rats were randomly divided into two groups: control and experimental. In the experimental group, we administered 0.06mg/kg intraperitoneal dose of zoledronic acid (ZA) 7 and 14 days prior to maxillary second molar extraction. At two, four and six weeks after tooth extraction, the animals were euthanized, and we dissected the maxilla following histological procedures. We stained serial slides with hematoxylin and eosin and Masson?s trichrome. The samples were harvested for macroscopic, radiologic and histological evaluation of bone changes. At two weeks postextraction, we observed exposed necrotic bone in dental socket areas in experimental groups. Radiological analysis revealed osteolytic lesions accompanied by extensive destruction and sequestrum formation in the same group. Histological examination confirmed the absence of necrotic bone in control groups in contrast with the experimental groups. The percentage of empty lacunae and the number of osteoclasts and the necrotic bone area were significantly increased (p<0.05) in the experimental groups. The animal model using ZA administration to prior dental extraction successfully mimicked human BRONJ lesions. Also, the model was easily replicated, inexpensive and showed different features than other previous BRONJ models. es
dc.title Dental extraction following zoledronate, induces osteonecrosis in rat´s jaw es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.21609 es
dc.type.hasVersion VoR es_ES

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